INT30920

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.91
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
neurons 4
plasma 2
pituitary 2
DRG 2
spinal cord dorsal horn 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 38 100.00 Very High Very High Very High
Dynorphin 24 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Morphine 19 99.98 Very High Very High Very High
mu opioid receptor 12 99.98 Very High Very High Very High
opiate 6 99.82 Very High Very High Very High
narcan 8 99.72 Very High Very High Very High
Spinal cord 56 99.64 Very High Very High Very High
spinal dorsal horn 1 99.64 Very High Very High Very High
intrathecal 8 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 98.24 Very High Very High Very High
INFLAMMATION 10 97.68 Very High Very High Very High
Injury 10 97.22 Very High Very High Very High
Interstitial Cystitis 12 93.80 High High
Depression 1 93.60 High High
Nervous System Injury 8 93.36 High High
Cystitis 5 92.00 High High
Insulin Resistance 15 85.84 High High
Diabetes Mellitus 32 83.04 Quite High
Pain 18 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone pretreatment enhanced the expression of Fos-IR neurons on the ipsilateral SpVc.
Positive_regulation (enhanced) of Gene_expression (expression) of Fos-IR in neurons associated with narcan
1) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.38
Naloxone pretreatment enhanced the expression of Fos-IR neurons on the ipsilateral SpVc.
Positive_regulation (enhanced) of Gene_expression (expression) of Fos-IR in neurons associated with narcan
2) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.38
These data indicate that chronic administration of cocaine stimulates the endogenous opiate system, elevating the levels of IR-BE in the pituitary and promoting beta-endorphin release.
Positive_regulation (elevating) of Gene_expression (levels) of IR-BE in pituitary associated with opiate and cocaine
3) Confidence 0.38 Published 1988 Journal Life Sci. Section Abstract Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.38
MOR IR levels had recovered 12 hours later.
Positive_regulation (recovered) of Gene_expression (recovered) of IR associated with mu opioid receptor
4) Confidence 0.37 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17366605 Disease Relevance 0.08 Pain Relevance 1.08
LC destruction failed, in contrast, to modify levels of ir-VP, ir-DYN, ir-DYN, ir-alpha-NE or ir-ME in any of the above structures.
Neg (failed) Positive_regulation (modify) of Gene_expression (levels) of ir-alpha-NE associated with dynorphin and locus ceruleus
5) Confidence 0.35 Published 1984 Journal Brain Res. Section Abstract Doc Link 6144361 Disease Relevance 0.09 Pain Relevance 1.33
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Positive_regulation (measuring) of Gene_expression (injection) of insulin in plasma
6) Confidence 0.31 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.13 Pain Relevance 0.07
P2X1-IR overlapped with P2X3-IR, though each was also found alone.
Positive_regulation (overlapped) of Gene_expression (overlapped) of P2X3-IR
7) Confidence 0.29 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11118807 Disease Relevance 0.09 Pain Relevance 0.14
P2X1-IR overlapped with P2X3-IR, though each was also found alone.
Positive_regulation (overlapped) of Gene_expression (overlapped) of P2X1-IR
8) Confidence 0.29 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11118807 Disease Relevance 0.09 Pain Relevance 0.14
Ovariectomy produced an increase in the levels of ir-Dyn A, Dyn B, alpha-nEnd, beta-nEnd, and LE 2 weeks after surgery, but, in contrast to castration, no significant decrease was seen 3 days after ovariectomy.
Positive_regulation (increase) of Gene_expression (levels) of ir-Dyn
9) Confidence 0.20 Published 1986 Journal Endocrinology Section Abstract Doc Link 2876888 Disease Relevance 0 Pain Relevance 0.24
Repetitive intrathecal injection of morphine increased the expression of AM-like immunoreactivity (AM-IR) in the spinal dorsal horn and dorsal root ganglion (DRG) neurons.
Positive_regulation (increased) of Gene_expression (expression) of AM-IR in DRG associated with ganglion cysts, dorsal root ganglion, spinal dorsal horn, morphine and intrathecal
10) Confidence 0.12 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20844145 Disease Relevance 0.41 Pain Relevance 1.19
The levels of Homa-IR in the YYJT and experimental groups were significantly increased (P < 0.001) compared to the control group after the model was established, but no significant difference was noted between the experimental and YYJT groups.
Positive_regulation (increased) of Gene_expression (levels) of Homa-IR
11) Confidence 0.04 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876602 Disease Relevance 0.17 Pain Relevance 0
Rodent models of bladder inflammation using either intravesical mustard oil [26] or intraperitoneal injection of cyclophosphamide [14] have demonstrated increases in CGRP- and SP-IR in bladder afferent neurons and central projections.
Positive_regulation (increases) of Gene_expression (projections) of SP-IR in afferent neurons associated with inflammation, substance p and calcitonin gene-related peptide
12) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.89 Pain Relevance 1.38
Similarly, the antisense oligodeoxynucleotide virtually abolished formalin-induced expression of c-Fos-like immunoreactivity (Fos-IR) in the spinal cord dorsal horn ipsilateral to injection.
Positive_regulation (formalin-induced) of Gene_expression (expression) of Fos-IR in spinal cord dorsal horn associated with dorsal horn and spinal cord
13) Confidence 0.03 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15388298 Disease Relevance 0.43 Pain Relevance 0.40
Under normal circumstances (i.e., in the absence of injury), a large percentage of cells express low levels of GAP43-IR (Van der Zee et al., 1989; Schreyer and Skene, 1991) with a small percentage expressing elevated GAP43-IR levels.
Positive_regulation (elevated) of Gene_expression (expressing) of GAP43-IR associated with injury
14) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.52 Pain Relevance 0.20

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