INT309251

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OGDHL) oxidoreductase activity (OGDHL)
Anatomy Link Frequency
brain 1
OGDHL (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 93.40 High High
gABA 18 89.12 High High
nMDA receptor 3 67.96 Quite High
Glutamate 8 58.96 Quite High
withdrawal 1 53.80 Quite High
alcohol 1 38.72 Quite Low
Multiple sclerosis 4 38.16 Quite Low
Sicca syndrome 4 25.12 Quite Low
Dopamine 14 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 3 98.50 Very High Very High Very High
Thiamine Deficiency 1 97.20 Very High Very High Very High
Wernicke Encephalopathy 1 93.44 High High
Anxiety Disorder 2 86.20 High High
Stress 6 68.96 Quite High
Apoptosis 2 63.44 Quite High
Frailty 3 40.68 Quite Low
Ataxia 73 39.52 Quite Low
Demyelinating Disease 5 38.16 Quite Low
Cerebellar Ataxia 37 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another mechanism of cerebellar toxicity of ethanol is linked to the effects on thiamine, an essential cofactor of alpha-ketoglutarate dehydrogenase, pyruvate dehydrogenase and transketolase, 3 key-enzymes of energy metabolism and lipid synthesis in the brain [95].
Gene_expression (synthesis) of alpha-ketoglutarate dehydrogenase in brain associated with toxicity
1) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.64 Pain Relevance 0.29

General Comments

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