INT30926

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 2.14
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
uterine 8
eyes 2
liver 2
epithelial cell 2
lung 2
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 45 100.00 Very High Very High Very High
opiate 1 98.92 Very High Very High Very High
antagonist 1 98.64 Very High Very High Very High
narcan 3 98.16 Very High Very High Very High
agonist 40 93.28 High High
ischemia 1 87.04 High High
Opioid 2 56.80 Quite High
Dismenorea 8 53.88 Quite High
halothane 1 45.44 Quite Low
anesthesia 2 44.64 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 46 100.00 Very High Very High Very High
Aggression 4 100.00 Very High Very High Very High
Asthma 42 93.20 High High
Occupational Lung Diseases 3 90.52 High High
Diabetic Retinopathy 1 90.00 High High
Retinal Neovascularization 1 88.44 High High
Cv Unclassified Under Development 1 87.04 High High
Targeted Disruption 11 85.36 High High
Injury 1 80.00 Quite High
Diabetes Mellitus 72 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.
Spec (examined) Regulation (effects) of Gene_expression (aggression) of PLG associated with antagonist, aggression, narcan and opiate
1) Confidence 0.45 Published 1986 Journal Life Sci. Section Abstract Doc Link 2877382 Disease Relevance 0.33 Pain Relevance 0.35
We then assessed the impact of COX-2 down-regulation on airway inflammation, lung function, and PG production.


Regulation (regulation) of Gene_expression (production) of PG in lung associated with inflammation
2) Confidence 0.18 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.70 Pain Relevance 0.08
In our study, there was no statistically significant difference between PEDF expression in eyes receiving rAAV-angiostatin and the contralateral eyes receiving rAAV-lacZ.
Neg (no) Regulation (difference) of Gene_expression (expression) of angiostatin in eyes
3) Confidence 0.16 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.75 Pain Relevance 0.04
The expression of plasminogen mRNA from hepatocyte is dependent on the cell density and stimulation [47] and is solely expressed in liver.
Regulation (dependent) of Gene_expression (expression) of plasminogen mRNA in liver
4) Confidence 0.08 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.15 Pain Relevance 0.03
The concentrations of pro-u-PA, plasminogen and Spectrozyme UK were as 20 nM, 5 nM and 100 ?
Regulation (were) of Gene_expression (concentrations) of plasminogen
5) Confidence 0.04 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707035 Disease Relevance 0 Pain Relevance 0
The objectives of this study were to evaluate the expression and activities of calcium-independent Group VI and Group IVC PLA2 (PLA2G6 and PLA2G4C) and calcium-dependent Group IVA PLA2 (PLA2G4A) enzymes in the regulation of bovine uterine endometrial epithelial cell PG production.


Regulation (regulation) of Gene_expression (production) of PG in epithelial cell
6) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0
The intracellular PLA2G4 and PLA2G6 enzymes are specifically important in the regulation of PG biosynthesis because their sites of action are the perinuclear membranes where down-stream AA metabolizing enzymes (cyclooxygenases and PG synthases) reside.
Regulation (regulation) of Gene_expression (biosynthesis) of PG
7) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0.07
Although PLA2 activation catalyzes the rate-limiting step in PG biosynthesis, most investigations of the mechanisms and regulation of uterine PG production have focused on the activation and expression of down-stream enzymes, such as the cyclooxygenases and PG synthases.
Regulation (regulation) of Gene_expression (production) of PG in uterine
8) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0.03
production led to studies that examined the effects of PLA2G6 overexpression on PG production.
Spec (examined) Regulation (effects) of Gene_expression (production) of PG
9) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0.09 Pain Relevance 0
Together, the data indicate that uterine PG production is regulated, at least in part, by the expression and activity of PLA2 enzymes and that specific PLA2 isotypes may regulate the production of specific PGs.


Regulation (regulated) of Gene_expression (production) of PG in uterine
10) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0.07 Pain Relevance 0
Surprisingly, none of these studies identified consistent changes in expression of protein or mRNA for PLA2G4A in association with alterations in PG production.
Regulation (alterations) of Gene_expression (production) of PG
11) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0.05
Results indicate that in addition to PLA2G4A, PLA2G6 and PLA2G4C contribute to regulation of uterine cell PG production and these latter two enzymes are activated in response to oxytocin and INFT, respectively.


Regulation (regulation) of Gene_expression (production) of PG in uterine
12) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0.05 Pain Relevance 0.12
Despite their importance in uterine PG production, little is known concerning the specific PLA2 enzymes that regulate arachidonic acid liberation in the uterine endometrium.
Regulation (importance) of Gene_expression (production) of PG in uterine
13) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0

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