INT309303

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (ST8SIA2) Golgi apparatus (ST8SIA2) carbohydrate metabolic process (ST8SIA2)
Anatomy Link Frequency
joint 1
neuronal 1
ST8SIA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 99.32 Very High Very High Very High
tetrodotoxin 78 95.88 Very High Very High Very High
Pain 2 94.96 High High
Sciatic nerve 1 94.40 High High
dexamethasone 1 92.12 High High
Piles 4 79.60 Quite High
anesthesia 1 68.72 Quite High
Spinal cord 1 64.16 Quite High
Lasting pain 1 63.56 Quite High
Ziconotide 2 59.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 99.32 Very High Very High Very High
Pain 2 94.96 High High
Arthralgia 1 94.32 High High
Toxicity 12 82.32 Quite High
Anorectal Disorders 4 79.60 Quite High
Frailty 1 64.44 Quite High
Tension-type Headache 2 14.56 Low Low
Shellfish Poisoning 11 5.00 Very Low Very Low Very Low
Heart Arrhythmia 5 5.00 Very Low Very Low Very Low
Channelopathies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liposome formulations of STX for slow and site-directed release for prolonged anaesthesia have since been postulated as a putative treatment of localized pain and severe joint pain [151].
Positive_regulation (formulations) of STX in joint associated with pain and arthralgia
1) Confidence 0.11 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.65 Pain Relevance 0.74
If mutated to the neuronal-specific amino acid phenylalanine channels acquire a high sensitivity for STX block, similar to wild-type neuronal channels.
Positive_regulation (sensitivity) of STX in neuronal
2) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.18

General Comments

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