INT309321

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2) cytoplasm (MAP2)

Anatomy Link Frequency dendrites 2 MAP2 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 3 28.52 glial activation 5 5.00 Inflammation 5 5.00 imagery 5 5.00 ketamine 3 5.00 cytokine 1 5.00 Central nervous system 1 5.00 Analgesic 1 5.00 ischemia 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Infection 17 96.76 Acquired Immune Deficiency Syndrome Or Hiv Infection 22 92.60 Gliosis 4 70.68 Viral Meningitis 8 56.36 Urological Neuroanatomy 18 33.36 Injury 10 5.00 INFLAMMATION 5 5.00 Disease 5 5.00 Neurological Disease 4 5.00 Death 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Decreases in the expression of synaptophysin (SYN), an integral protein in presynaptic terminals, and microtubule-associated protein 2 (MAP2), a marker for neuronal cell bodies and dendrites, reflect neurodegeneration severity and have been found to correlate to the degree of neurocognitive impairment in persons with HIV [26].

Negative_regulation (Decreases) of Gene_expression (expression) of microtubule-associated protein 2 in dendrites associated with acquired immune deficiency syndrome or hiv infection

1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.51 Pain Relevance 0

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