INT309322

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.64
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AIF1) plasma membrane (AIF1) cytoskeleton (AIF1)
nucleus (AIF1) response to stress (AIF1) cytoplasm (AIF1)
Anatomy Link Frequency
macrophage 1
neuronal 1
brains 1
microglia 1
AIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 53 99.38 Very High Very High Very High
Multiple sclerosis 6 84.64 Quite High
ischemia 6 83.40 Quite High
fibrosis 4 80.96 Quite High
glial activation 30 78.80 Quite High
imagery 32 54.08 Quite High
cytokine 16 5.44 Low Low
ketamine 18 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.38 Very High Very High Very High
Infection 116 87.76 High High
Disease 32 86.76 High High
Demyelinating Disease 6 84.64 Quite High
Cv Unclassified Under Development 11 83.40 Quite High
Neurological Disease 24 82.64 Quite High
Fibrosis 4 80.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 158 79.40 Quite High
Gliosis 24 72.88 Quite High
Injury 62 62.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible role of this mechanism in the present study is supported by the finding that MN-treated animals had lower levels of IBA-1 expression, a marker increased with microglial activation, compared to the untreated cohort.
Gene_expression (expression) of IBA-1
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.54 Pain Relevance 0.12
Calcium binding adaptor protein 1, IBA-1 is expressed by resting microglia and is upregulated when these cells are activated [27].
Gene_expression (expressed) of IBA-1 in microglia
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.06 Pain Relevance 0
Levels of IBA-1 expression in the MN-treated animals, however, still remained higher than levels in uninfected animals.
Gene_expression (Levels) of IBA-1
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.54 Pain Relevance 0.12
There was substantially less IBA-1 expression in brains of animals from both MN-treated cohorts indicating reduced microglial activation.
Gene_expression (expression) of IBA-1 in brains
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.09 Pain Relevance 0
SYN, MAP2, and neuronal counts were found to be higher in minocycline-treated animals compared to untreated animals while GFAP and IBA-1 expression were decreased compared to controls.
Gene_expression (expression) of IBA-1 in neuronal
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2866543 Disease Relevance 0.14 Pain Relevance 0
Levels of IBA-1 expression in the MN-treated animals, however, still remained higher than levels in uninfected animals.
Gene_expression (expression) of IBA-1
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.54 Pain Relevance 0.12
Inflammatory foci were composed largely of Iba-1 expressing cells, compatible with macrophage lineage; moreover, 60–80% of the Iba-1 positive cells also expressed the CD68 glycoprotein, suggestive of an activated phenotype (Figure 3).
Gene_expression (expressing) of Iba-1 in macrophage associated with inflammation
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009713 Disease Relevance 0.74 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox