INT309338

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.44

cytoskeletal protein binding (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) cytoplasm (Gphn)

Anatomy Link Frequency neurons 2 Gphn (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 5 97.56 gABA 28 93.08 Neurotransmitter 30 92.88 Spinal cord 48 74.40 agonist 4 52.48 nMDA receptor 3 51.72 interneuron 1 48.40 GABAergic 17 24.64 midbrain 8 5.00 Hippocampus 7 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 10 5.00 Pain 3 5.00 Targeted Disruption 2 5.00 Nociception 2 5.00 Sleep Disorders 1 5.00 Death 1 5.00 Lung Cancer 1 5.00 Spasticity 1 5.00 Depression 1 5.00 Muscle Hypertonia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Experiments using the GlyR antagonist strychnine and L-type Ca+2 blockers on spinal neurons suggest that GlyR activation leads to Ca+2 transients that in turn cause accumulation of the anchoring protein Gephyrin and GlyR.

Positive_regulation (cause) of Positive_regulation (accumulation) of Gephyrin in neurons associated with antagonist

1) Confidence 0.09 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.44

General Comments

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