INT309344

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Glyr1) nucleus (Glyr1) DNA binding (Glyr1)
cellular_component (Glyr1)
Anatomy Link Frequency
synapse 1
Glyr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 3 90.08 High High
medulla 8 88.32 High High
Hippocampus 7 88.28 High High
antagonist 8 84.28 Quite High
Spinal cord 82 81.76 Quite High
Pyramidal cell 1 75.72 Quite High
Central nervous system 14 56.00 Quite High
Dorsal horn neuron 3 47.84 Quite Low
cerebral cortex 3 39.64 Quite Low
potassium channel 1 35.92 Quite Low
Disease Link Frequency Relevance Heat
Spasticity 3 77.88 Quite High
Tremor 2 77.28 Quite High
Disease 3 76.60 Quite High
Toxicity 1 57.00 Quite High
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Polio 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, GlyR levels and subunit composition could be manipulated in mice and then studied at the channel, synapse, and behavioral levels of analysis (Hartenstein et al., 1996; Becker et al., 2000).
Regulation (manipulated) of GlyR in synapse
1) Confidence 0.13 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2889717 Disease Relevance 0.36 Pain Relevance 0.17
-alanine and taurine uptake inhibitor guanidinoethanesulfonic acid indicated that the modulation of these transporters could regulate tonic GlyR activation.
Regulation (regulate) of GlyR
2) Confidence 0.02 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.34

General Comments

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