INT309357

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.23

cell differentiation (Ptf1a) nucleus (Ptf1a) intracellular (Ptf1a) embryo development (Ptf1a) DNA binding (Ptf1a) cytoplasm (Ptf1a)

Anatomy Link Frequency amacrine cells 2 Ptf1a (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 17 88.44 Spinal cord 48 78.36 gABA 28 68.52 Dorsal horn 5 60.28 Dorsal horn neuron 1 46.92 Neurotransmitter 30 5.00 midbrain 8 5.00 Hippocampus 7 5.00 medulla 6 5.00 Thalamus 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 2 12.76 Ganglion Cysts 10 5.00 Pain 3 5.00 Nociception 2 5.00 Sleep Disorders 1 5.00 Death 1 5.00 Lung Cancer 1 5.00 Spasticity 1 5.00 Depression 1 5.00 Muscle Hypertonia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inactivation of Ptf1a prevents differentiation of horizontal and amacrine cells during retina development (Nakhai et al., 2007).

Negative_regulation (prevents) of Positive_regulation (Inactivation) of Ptf1a in amacrine cells

1) Confidence 0.14 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.23

General Comments

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