INT309362

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.32

aging (Slc32a1)

Anatomy Link Frequency neural 2 Slc32a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neurotransmitter 60 99.78 Spinal cord 96 96.80 GABAergic 34 86.24 nMDA receptor 6 64.68 gABA 56 35.20 Glutamate 6 27.08 Dorsal horn 10 20.68 Dorsal horn neuron 2 7.32 midbrain 16 5.00 Hippocampus 14 5.00

Disease Link Frequency Relevance Heat Lung Cancer 2 71.84 Ganglion Cysts 20 45.68 Pain 6 5.00 Targeted Disruption 4 5.00 Nociception 4 5.00 Sleep Disorders 2 5.00 Death 2 5.00 Spasticity 2 5.00 Depression 2 5.00 Muscle Hypertonia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The glycinergic neurotransmitter phenotype requires the expression of the transporters GlyT2 and VIAAT for proper neurotransmission (reviewed in Betz and Laube, 2006).

Positive_regulation (requires) of Gene_expression (expression) of VIAAT associated with neurotransmitter

1) Confidence 0.13 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.24

Knockdown of Lhx1 and Lhx5 results in decreased expression of VIAAT, although they do not appear to be obligatory determinant of inhibitory neural phenotypes and appear to play no direct role in determining GlyT2 expression (Pillai et al., 2007).

Positive_regulation (results) of Gene_expression (expression) of VIAAT in neural

2) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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