INT309362

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc32a1)
Anatomy Link Frequency
neural 2
Slc32a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 60 99.78 Very High Very High Very High
Spinal cord 96 96.80 Very High Very High Very High
GABAergic 34 86.24 High High
nMDA receptor 6 64.68 Quite High
gABA 56 35.20 Quite Low
Glutamate 6 27.08 Quite Low
Dorsal horn 10 20.68 Low Low
Dorsal horn neuron 2 7.32 Low Low
midbrain 16 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 2 71.84 Quite High
Ganglion Cysts 20 45.68 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Spasticity 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Muscle Hypertonia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glycinergic neurotransmitter phenotype requires the expression of the transporters GlyT2 and VIAAT for proper neurotransmission (reviewed in Betz and Laube, 2006).
Positive_regulation (requires) of Gene_expression (expression) of VIAAT associated with neurotransmitter
1) Confidence 0.13 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.24
Knockdown of Lhx1 and Lhx5 results in decreased expression of VIAAT, although they do not appear to be obligatory determinant of inhibitory neural phenotypes and appear to play no direct role in determining GlyT2 expression (Pillai et al., 2007).
Positive_regulation (results) of Gene_expression (expression) of VIAAT in neural
2) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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