INT309363

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.37 Pain Relevance 0.30

aging (Slc32a1)

Slc32a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Substantia nigra 146 92.64 GABAergic 119 88.56 gABA 104 84.16 ischemia 156 77.68 Hippocampus 13 35.12 midbrain 20 27.12 Glutamate 17 26.88 Thalamus 16 8.16 Spinal cord 48 5.00 Dopamine 38 5.00

Disease Link Frequency Relevance Heat Generalized Anxiety Disorder 27 87.48 Apoptosis 26 78.64 Cv Unclassified Under Development 144 77.68 Targeted Disruption 2 72.88 Injury 36 52.40 Rhinitis 6 26.16 Parkinson's Disease 32 5.00 Hypoxia 22 5.00 Disease 20 5.00 Encephalopathy 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Slides from sham rats were processed in parallel with sections from postischemic rats as the positive control for the GAD67 and VGAT immunostaining.

Regulation (control) of VGAT

1) Confidence 0.37 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.22 Pain Relevance 0.09

Intense VGAT-immunoreactivity (VGAT-ir) was observed in the SNR, SNL, and SNC (Figure 6).

Regulation (immunoreactivity) of VGAT-ir

2) Confidence 0.19 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.08 Pain Relevance 0.21

Understanding the regulation of “terminal differentiation” genes such as GlyT2 or VIAAT is a particularly interesting problem given that many genes associated with the differentiated phenotype display profoundly similar expression patterns across species, yet do not share significant sequence similarity in their regulatory regions.

Regulation (regulation) of VIAAT

3) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.07 Pain Relevance 0

General Comments

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