INT309370

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gphn) DNA binding (Glyr1) cytoplasm (Gphn)
cytoskeletal protein binding (Gphn) oxidoreductase activity (Glyr1) nucleus (Glyr1)
Anatomy Link Frequency
neurons 3
Glyr1 (Mus musculus)
Gphn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 98.64 Very High Very High Very High
gABA 28 95.24 Very High Very High Very High
Neurotransmitter 30 95.04 Very High Very High Very High
Spinal cord 48 76.56 Quite High
agonist 4 54.64 Quite High
nMDA receptor 3 53.88 Quite High
interneuron 1 48.40 Quite Low
GABAergic 17 24.64 Low Low
midbrain 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Lung Cancer 1 5.00 Very Low Very Low Very Low
Spasticity 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Muscle Hypertonia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments using the GlyR antagonist strychnine and L-type Ca+2 blockers on spinal neurons suggest that GlyR activation leads to Ca+2 transients that in turn cause accumulation of the anchoring protein Gephyrin and GlyR.
Positive_regulation (activation) of GlyR in neurons Positive_regulation (cause) of Positive_regulation (accumulation) of Gephyrin in neurons associated with antagonist
1) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.47

General Comments

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