INT309385

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.98
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
brains 2
gonad 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 57 65.68 Quite High
Inflammatory response 2 54.60 Quite High
alcohol 6 42.08 Quite Low
Hippocampus 30 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 21 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 99.04 Very High Very High Very High
Disease 231 97.96 Very High Very High Very High
Increased Venous Pressure Under Development 20 95.44 Very High Very High Very High
Stress 57 92.08 High High
Hypoxia 33 88.44 High High
Hypertension 102 81.76 Quite High
Heart Disease 6 81.20 Quite High
Stroke 4 80.60 Quite High
Cerebrovascular Disease 3 75.52 Quite High
Neurodegenerative Disease 9 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrated that Tg2576 mice exhibit an increased phosphorylation of eNOS at serine 1177. eNOS expression has been shown to be decreased in the brains of AD patients [44].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of eNOS in brains associated with disease
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.40 Pain Relevance 0
Moreover, male androgen receptor knockout mice show decreased aortic eNOS expression and phosphorylated eNOS compared to wild type mice [28].
Positive_regulation (phosphorylated) of Phosphorylation (phosphorylated) of eNOS associated with targeted disruption
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.28 Pain Relevance 0
It should be noted that eNOS phosphorylation at serine 1177 in castrated animals was elevated compared to gonad intact animals (Figure 8B).
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of eNOS in gonad
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.06 Pain Relevance 0
Our data indicated that the levels of phospho-eNOS in cortical fractions were significantly increased in the Tg2576 mice (overall p?
Positive_regulation (increased) of Phosphorylation (phospho) of eNOS
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.20 Pain Relevance 0.07
This effect is mediated primarily by Akt-dependent phosphorylation of eNOS at serine 1177 [30], [31].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of eNOS
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 1.52 Pain Relevance 0
This would be explained if EETs/DHETs stimulate NO formation, either by causing eNOS phosphorylation or by enhancing Ca2+ signaling following activation of cation channels of the transient receptor potential gene family (TRPV4) [24, 29].
Positive_regulation (causing) of Phosphorylation (phosphorylation) of eNOS
6) Confidence 0.18 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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