INT309477

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cdk1) protein complex assembly (Cdk1) cytoplasm (Cdk1)
mitosis (Cdk1) nucleus (Cdk1) cell cycle (Cdk1)
Cdk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 56.64 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 72.88 Quite High
Disease 50 70.20 Quite High
Targeted Disruption 45 63.76 Quite High
Death 9 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Lifespan 5 5.00 Very Low Very Low Very Low
Dna Damage 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Positive_regulation (activation) of Cdk1
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.14 Pain Relevance 0
For Cdk1 kinase assay, 500 µl of protein samples (containing 650 µg protein) was incubated with 20 µl HCK gel (MBL International) for 2 h at 4°C.
Positive_regulation (incubated) of Cdk1
2) Confidence 0.32 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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