INT309494

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.31 Pain Relevance 0.04

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax) cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)

Bax (Mus musculus)

Pain Link Frequency Relevance Heat addiction 6 76.64 cerebral cortex 6 5.00 imagery 4 5.00 cINOD 2 5.00 Inflammation 2 5.00 antagonist 2 5.00 anesthesia 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 120 99.48 Death 50 86.16 Infection 5 54.12 Cancer 4 50.00 Toxicity 3 22.96 Adenovirus Infection 2 22.00 Disease 50 5.00 Targeted Disruption 33 5.00 Cytomegalovirus Infection 7 5.00 Aging 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

First, the interaction of BAX with a binding partner could be affected by low levels of BAX protein, especially if the binding partner had a reduced affinity for BAX in its globular conformation.

Negative_regulation (reduced) of BAX Binding (affinity) of

1) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.41 Pain Relevance 0.04

GFP-BAX aggregation is impaired at sub-lethal levels of expression

Negative_regulation (impaired) of GFP-BAX Binding (aggregation) of

2) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.64 Pain Relevance 0

Acetylation of Ku70 seems to inhibit the interaction with Bax and promote apoptosis (Cohen et al., 2004).

Negative_regulation (inhibit) of Bax Binding (interaction) of associated with apoptosis

3) Confidence 0.20 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.25 Pain Relevance 0

General Comments

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