INT309494

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.31
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 76.64 Quite High
cerebral cortex 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 120 99.48 Very High Very High Very High
Death 50 86.16 High High
Infection 5 54.12 Quite High
Cancer 4 50.00 Quite Low
Toxicity 3 22.96 Low Low
Adenovirus Infection 2 22.00 Low Low
Disease 50 5.00 Very Low Very Low Very Low
Targeted Disruption 33 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 7 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, the interaction of BAX with a binding partner could be affected by low levels of BAX protein, especially if the binding partner had a reduced affinity for BAX in its globular conformation.
Negative_regulation (reduced) of BAX Binding (affinity) of
1) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.41 Pain Relevance 0.04
GFP-BAX aggregation is impaired at sub-lethal levels of expression
Negative_regulation (impaired) of GFP-BAX Binding (aggregation) of
2) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.64 Pain Relevance 0
Acetylation of Ku70 seems to inhibit the interaction with Bax and promote apoptosis (Cohen et al., 2004).
Negative_regulation (inhibit) of Bax Binding (interaction) of associated with apoptosis
3) Confidence 0.20 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.25 Pain Relevance 0

General Comments

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