INT309506

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.19 Pain Relevance 0

nucleus (Tdp1) cytoplasm (Tdp1) nuclease activity (Tdp1)

Tdp1 (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 6 5.00 imagery 2 5.00 anesthesia 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Cerebellar Ataxia 1 98.44 Disease 50 97.20 Werner Syndrome 1 91.80 Cockayne Syndrome 1 88.44 Aging 6 87.04 Neurodegenerative Disease 2 84.96 Targeted Disruption 33 64.52 Lifespan 5 59.68 Dna Damage 4 41.84 Stress 5 21.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The autosomal recessive cerebellar ataxias, including AOA1/EAOH (Date et al., 2001), AOA2 (Suraweera et al., 2007), and SCAN1 (Takashima et al., 2002; El-Khamisy et al., 2005), are also caused by mutations of DNA repair genes.

Positive_regulation (caused) of SCAN1 associated with cerebellar ataxia

1) Confidence 0.23 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 1.19 Pain Relevance 0

General Comments

This test has worked.