INT309509

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Xrcc6, Htt) cytoplasm (Xrcc6, Htt) nucleus (Xrcc6, Htt)
lyase activity (Xrcc6) Golgi apparatus (Htt) endoplasmic reticulum (Htt)
Xrcc6 (Mus musculus)
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 50 95.52 Very High Very High Very High
Lifespan 5 93.68 High High
Targeted Disruption 33 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Dna Damage 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant huntingtin impairs Ku70-mediated DNA repair

Mutant huntingtin prevents interaction of the DNA damage repair complex component Ku70 with damaged DNA, blocking repair of double-strand breaks.


Negative_regulation (prevents) of Ku70 Binding (interaction) of huntingtin
1) Confidence 0.31 Published 2010 Journal The Journal of Cell Biology Section Title Doc Link PMC2867301 Disease Relevance 0.41 Pain Relevance 0

General Comments

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