INT30954

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.40
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
plasma 1
neurons 1
Crh (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 6 99.60 Very High Very High Very High
antagonist 13 99.24 Very High Very High Very High
Opioid 6 98.56 Very High Very High Very High
mu opioid receptor 1 98.56 Very High Very High Very High
opioid receptor 4 96.64 Very High Very High Very High
narcan 14 96.60 Very High Very High Very High
Enkephalin 3 85.60 High High
Dynorphin 5 84.64 Quite High
opiate 5 78.96 Quite High
Intracerebroventricular 1 59.40 Quite High
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
Urological Neuroanatomy 12 95.20 Very High Very High Very High
Immunization 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that both acute immobilization stress and CRF can inhibit the LH secretory activity without mediation by EOP neurons.
CRF Negative_regulation (inhibit) of LH in neurons associated with stress
1) Confidence 0.46 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8866253 Disease Relevance 0.40 Pain Relevance 0.39
Inhibition of LH release by CRF may be partially mediated through hypothalamic beta-endorphin release.
CRF Negative_regulation (Inhibition) of LH
2) Confidence 0.32 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2963219 Disease Relevance 0 Pain Relevance 0.11
A third experiment, in which short term castrates were pretreated with an opioid antibody and then with CRF, resulted in a significant reduction of the CRF-induced reduction of serum LH levels.
CRF Negative_regulation (reduction) of serum LH associated with opioid
3) Confidence 0.29 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.53
In contrast, bilateral administration of beta-Funaltrexamine (antagonist of mu-opioid receptors) or naloxonazine (mu 1-antagonist) partially attenuated the inhibitory effect of rCRF on plasma LH levels.
rCRF Negative_regulation (effect) of LH in plasma associated with antagonist and mu opioid receptor
4) Confidence 0.13 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.66 Pain Relevance 0.43
Because endogenous opioid peptides (EOP) and CRF are activated during stress and decrease LH levels when injected centrally, we have explored the roles of these peptides in the stress-induced inhibition of LH secretion.
CRF Negative_regulation (decrease) of LH associated with stress and endogenous opioid
5) Confidence 0.10 Published 1986 Journal Endocrinology Section Abstract Doc Link 2877862 Disease Relevance 0.34 Pain Relevance 0.60

General Comments

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