INT30961

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 11.44
Pain Relevance 12.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
brain 3
juvenile 1
pituitary 1
platelet 1
brainstem 1
HTR2A (Homo sapiens)
HTR2A - T102C (4)
Pain Link Frequency Relevance Heat
Serotonin 160 100.00 Very High Very High Very High
Dopamine 145 100.00 Very High Very High Very High
gABA 22 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
Migraine 10 99.98 Very High Very High Very High
antagonist 71 99.96 Very High Very High Very High
alcohol 156 99.66 Very High Very High Very High
agonist 73 99.58 Very High Very High Very High
5HT 284 99.42 Very High Very High Very High
medulla 14 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 15 99.98 Very High Very High Very High
Schizophrenia 153 99.44 Very High Very High Very High
Anxiety Disorder 415 99.24 Very High Very High Very High
Epilepsy 4 99.20 Very High Very High Very High
Functional Bowel Disorder 3 99.20 Very High Very High Very High
Fibromyalgia 7 99.12 Very High Very High Very High
Coronary Artery Disease 13 98.80 Very High Very High Very High
Pain 14 98.40 Very High Very High Very High
Sprains And Strains 4 98.18 Very High Very High Very High
Coronary Heart Disease 1 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ibogaine's hallucinogenic effects may be explained by its interactions with 5-HT2A and 5-HT2C receptors, while its putative antiaddictive properties may result from its interactions with sigma 2 and opiate receptors.
5-HT2A Binding (interactions) of associated with opiate
1) Confidence 0.47 Published 2001 Journal Alkaloids Chem Biol Section Abstract Doc Link 11705117 Disease Relevance 0 Pain Relevance 0.19
The family history of migraine did not associate with 5-HT2A receptor gene polymorphism (p>0.05).
5-HT2A Neg (not) Binding (associate) of
2) Confidence 0.47 Published 2001 Journal J. Neurol. Sci. Section Body Doc Link 11489292 Disease Relevance 0 Pain Relevance 0
PHARMACOLOGICAL PROPERTIES: Aripiprazole is a quinolinone derivative with a high affinity for dopamine D2 and D3 receptors, and serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors.
5-HT2A Binding (affinity) of associated with dopamine and serotonin
3) Confidence 0.47 Published 2004 Journal Drugs Section Abstract Doc Link 15257633 Disease Relevance 0.54 Pain Relevance 0.33
[Changes of 5-HT2A receptor binding on platelet of patients with CAD and the effects of exercise test].
5-HT2A Binding (binding) of in platelet associated with coronary artery disease
4) Confidence 0.47 Published 1997 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Title Doc Link 10453517 Disease Relevance 0.78 Pain Relevance 0.08
The mean frontal to cerebellum radioactivity concentration ratio, an index of the [18F]setoperone specific binding to 5-HT2A receptors, was higher in treated than in untreated patients, when age was taken into account.
5-HT2A Binding (binding) of in cerebellum
5) Confidence 0.47 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9335087 Disease Relevance 0.26 Pain Relevance 0.22
As previously reported, amperozide displayed high affinity for serotonin 5-HT2A receptors (Ki = 16 nmol/L), and moderate affinity for striatal dopamine D2 (Ki = 540 nmol/L) and cortical alpha 1-adrenergic receptors (Ki = 172 nmol/L).
5-HT2A Binding (affinity) of associated with dopamine and serotonin
6) Confidence 0.47 Published 1997 Journal Biol. Psychiatry Section Abstract Doc Link 9270901 Disease Relevance 0 Pain Relevance 0.36
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT2A Neg (not) Binding (affinity) of in brain associated with potency
7) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.48
Moreover, reductions in cortical (one out of three reports) and limbic 5-HT1A (three out of three reports) and cortical (four out of four reports) and limbic 5-HT2A receptor binding (one out of two reports) were observed.
5-HT2A Binding (binding) of
8) Confidence 0.47 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19523490 Disease Relevance 1.14 Pain Relevance 0.16
MDL 100,907 demonstrated low nanomolar or subnanomolar binding in vitro at the 5-HT2A receptor and showed a > 100-fold separation from all other receptors measured.
5-HT2A Binding (binding) of
9) Confidence 0.47 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627580 Disease Relevance 0 Pain Relevance 0.17
This compound has a moderate affinity for 5-HT2A, adrenergic (?
5-HT2A Binding (affinity) of
10) Confidence 0.47 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671777 Disease Relevance 0.57 Pain Relevance 0.12
The enhancement of TRPV1 by 5-HT was significantly attenuated by selective 5-HT2 and 5-HT4 receptor antagonists, but not by a 5-HT3 receptor antagonist.
5-HT2 Binding (attenuated) of associated with antagonist
11) Confidence 0.36 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509739 Disease Relevance 0.08 Pain Relevance 0.35
LSD and MDMA share structural features with serotonin, and it appears to be the affinity of these agents for 5-HT2 receptors that correlate with psychedelic potency.
5-HT2 Binding (affinity) of associated with serotonin and potency
12) Confidence 0.36 Published 2004 Journal Harm Reduct J Section Body Doc Link PMC419978 Disease Relevance 0.54 Pain Relevance 0.65
Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome.
5-Ht2A Binding (Association) of in bowel associated with spastic colon
13) Confidence 0.36 Published 2004 Journal J. Clin. Gastroenterol. Section Title Doc Link 15232358 Disease Relevance 0.20 Pain Relevance 0.33
Both short-term and long-term treatment with fluoxetine increased the specific binding of [3H]mesulergine, a ligand for alL three 5-HT2 receptors.
5-HT2 Binding (ligand) of associated with fluoxetine
14) Confidence 0.36 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 11930908 Disease Relevance 0 Pain Relevance 0.91
Walitza et al.48 performed an association analysis of 5-HT2A polymorphism in 55 German children and adolescents with OCD, and also in 223 controls, and confirmed the association between the -1438A allele of the 5-HT2A gene and juvenile OCD.
5-HT2A Binding (association) of in juvenile associated with anxiety disorder
15) Confidence 0.36 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 1.07 Pain Relevance 0.15
Ifoxetine displayed weak or no interactions with 5-HT1, 5-HT2, alpha 1-, alpha 2- and beta-noradrenoceptors, histamine H1, muscarinic acetylcholine, opiate, GABA A, and benzodiazepine receptors in vitro, and with dopamine and 5-HT2 receptors in vivo.
5-HT2 Neg (no) Binding (interactions) of associated with dopamine, gaba and opiate
16) Confidence 0.36 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2877890 Disease Relevance 0 Pain Relevance 0.40
T102C polymorphism of the 5-HT2A receptor gene is not associated with the etiology of FS.
5-HT2A Binding (associated) of associated with fibrositis
17) Confidence 0.36 Published 2001 Journal Rheumatol. Int. Section Abstract Doc Link 11732859 Disease Relevance 0.56 Pain Relevance 0.47
Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine.
5-HT2A (T102C) Binding (Association) of associated with epilepsy and migraine
18) Confidence 0.36 Published 2001 Journal J. Neurol. Sci. Section Title Doc Link 11489292 Disease Relevance 0.29 Pain Relevance 0.19
In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol] [formula: see text] (MDL 100,907), a putative atypical antipsychotic, was characterized in vitro as a potent and selective ligand for the serotonin2A (5-HT2A) receptor and was evaluated in vitro and in vivo as a potent 5-HT2A receptor antagonist.
5-HT2A Binding (ligand) of associated with antagonist
19) Confidence 0.36 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627580 Disease Relevance 0 Pain Relevance 0.15
In summary, these preclinical data indicate that MDL 100,907 is a potent and selective ligand at the 5-HT2A receptor.
5-HT2A Binding (ligand) of
20) Confidence 0.36 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627580 Disease Relevance 0.17 Pain Relevance 0.28

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