INT3097

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.15
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
blood 1
plasma 1
hypophysis 1
brain 1
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 42 100.00 Very High Very High Very High
opiate 1 98.36 Very High Very High Very High
anesthesia 3 95.64 Very High Very High Very High
antagonist 3 95.12 Very High Very High Very High
Enkephalin 3 94.76 High High
qutenza 3 93.76 High High
cva 5 92.20 High High
cINOD 1 91.92 High High
aspirin 1 89.36 High High
Inflammation 28 85.92 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1 99.92 Very High Very High Very High
Hypertension 25 99.64 Very High Very High Very High
Targeted Disruption 10 95.76 Very High Very High Very High
Apoptosis 4 94.28 High High
Pressure And Volume Under Development 1 92.88 High High
Cv General 3 Under Development 3 92.20 High High
Hypotension 5 91.72 High High
INFLAMMATION 31 91.52 High High
Adhesions 18 88.32 High High
Nephrosclerosis 1 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We interpreted this drinking response as being the sum of morphine-induced drinking (following a permissive interaction between morphine and circulating angiotensin I or renin) and captopril-induced drinking (following a captopril-induced increase in circulating renin and angiotensin I levels).
renin Binding (interaction) of associated with morphine
1) Confidence 0.48 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 1.01
Pharmacokinetic interaction of the direct renin inhibitor aliskiren with furosemide and extended-release isosorbide-5-mononitrate in healthy subjects.
renin Binding (interaction) of
2) Confidence 0.47 Published 2008 Journal Cardiovascular therapeutics Section Title Doc Link 19035874 Disease Relevance 0 Pain Relevance 0
[The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex].
renin-angiotensin Binding (interaction) of in hypophysis
3) Confidence 0.42 Published 1996 Journal Fiziol Zh Im I M Sechenova Section Title Doc Link 8963340 Disease Relevance 0 Pain Relevance 0.09
This result pointed once again to a permissive interaction between morphine and circulating angiotensin I or renin.
renin Binding (interaction) of associated with morphine
4) Confidence 0.42 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 0.88
Diabetes is associated with renin suppression, and blacks have lower values of plasma renin activity than whites.
renin Binding (associated) of in plasma associated with diabetes mellitus
5) Confidence 0.39 Published 1978 Journal Geriatrics Section Abstract Doc Link 624453 Disease Relevance 0.58 Pain Relevance 0.14
Our results confirm the hypothesis that a low renal renin status is associated with low basal and stimulated renin release.
renin Binding (associated) of
6) Confidence 0.37 Published 1981 Journal Pflugers Arch. Section Abstract Doc Link 7033921 Disease Relevance 0.41 Pain Relevance 0.26
Evidence is also available indicating that sensory nerves, in interacting with other neurohormonal systems including the sympathetic nervous system, the renin-angiotensin aldosterone system, the endothelin system, and superoxide, regulate cardiovascular and renal function in such that they play a counter-balancing role in preventing salt-induced increases in blood pressure under pathophysiological conditions.
renin-angiotensin Binding (interacting) of in blood associated with pressure and volume under development
7) Confidence 0.37 Published 2007 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 17346127 Disease Relevance 0.79 Pain Relevance 0.17
These results pointed to the existence of a permissive interaction between morphine and the renin-angiotensin system.
renin Binding (interaction) of associated with morphine
8) Confidence 0.36 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 0.98
The data obtained suggest that the enzyme is an important link in the mechanism of interaction between the renin-angiotensin and enkephalinergic systems in rats.
renin-angiotensin Binding (interaction) of
9) Confidence 0.31 Published 1996 Journal Fiziol Zh Im I M Sechenova Section Abstract Doc Link 8963340 Disease Relevance 0 Pain Relevance 0.09
[The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex].
renin-angiotensin Binding (interaction) of in brain
10) Confidence 0.14 Published 1996 Journal Fiziol Zh Im I M Sechenova Section Title Doc Link 8963340 Disease Relevance 0 Pain Relevance 0.09
The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.
renin Neg (not) Binding (interact) of associated with hypertension
11) Confidence 0.14 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.75 Pain Relevance 0.16
We recently observed that rats harboring both human renin and angiotensinogen genes (dTGR) develop severe renal and cardiac damage, accompanied by increased NF-?
renin Binding (harboring) of
12) Confidence 0.11 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.61 Pain Relevance 0.14
Recent studies have suggested probable interaction between the renin-angiotensin and mesolimbic dopaminergic systems.
renin-angiotensin Binding (interaction) of
13) Confidence 0.05 Published 2009 Journal Acta. Biol. Hung. Section Abstract Doc Link 19700383 Disease Relevance 0 Pain Relevance 0.40

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