INT309716

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GOPC, CALM3, TRPV4) cytoplasm (GOPC, CALM3) nucleoplasm (CALM3)
small molecule metabolic process (CALM3) Golgi apparatus (GOPC) carbohydrate metabolic process (CALM3)
GOPC (Homo sapiens)
CALM3 (Homo sapiens)
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using different experimental strategies, we have demonstrated that an interaction between an N-terminal and a C-terminal site in TRPV4 is present at nanomolar Ca2+ concentrations (Fig. 8A), but becomes disrupted secondary to CaM binding to the TRPV4 C terminus at micromolar Ca2+ concentrations (Fig. 8B).
Fig Binding (interaction) of Positive_regulation (disrupted) of CaM Binding (binding) of TRPV4
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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