INT309727

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
C2 (Homo sapiens)
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 84.72 Quite High
TRP channel 16 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
qutenza 4 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar finding was observed when the CaM/C2 interaction was subjected to competition by C2 or N2 (Fig. 7E).
C2 Binding (interaction) of Fig
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
CaM competitively reduced this interaction in a Ca2+-dependent fashion with an IC50 of 166 nM in 100 µM Ca2+, a value that is in agreement with the Kd observed for its binding to C2 (see Fig. 1D).
C2 Binding (binding) of Fig
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.04
In AlphaScreen-based C2 interaction assays, both constructs, WIA and KRA, had a significantly lower binding affinity to the C2 fragment (Fig. 3C,E) with respective AlphaScreen signals of 48.4±5.5% and 14.8±2.1% of the wild type at the given component concentrations.
C2 Binding (affinity) of Fig
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
In AlphaScreen-based C2 interaction assays, both constructs, WIA and KRA, had a significantly lower binding affinity to the C2 fragment (Fig. 3C,E) with respective AlphaScreen signals of 48.4±5.5% and 14.8±2.1% of the wild type at the given component concentrations.
C2 Binding (affinity) of Fig
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0

General Comments

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