INT309780

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.30
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (PTH1R) intracellular (PTH1R) cytoplasm (PTH1R)
signal transducer activity (PTH1R) cell-cell signaling (PTH) extracellular space (PTH)
Anatomy Link Frequency
Parathyroid 2
PTH (Homo sapiens)
PTH1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 102 89.32 High High
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 122 89.32 High High
Apoptosis 6 60.40 Quite High
Hypertrophy 4 48.64 Quite Low
Osteophyte 10 30.08 Quite Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Joint Instability 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loop sampling of ICM can not reliably predict such large loops, although structural characterisation of ECL1 of the PTH1R has shown the existence of a central helical region of the loop that interact with PTH, hinting at that some of the loops characteristics are found by the modelling process [26].
PTH Binding (interact) of PTH1R
1) Confidence 0.12 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
For the extracellular domain of PTH2R and TIP39, the complex between PTH1R and PTH was used as template [PDB:3C4M] [7].
PTH Binding (complex) of PTH1R
2) Confidence 0.09 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The extended conformation of PTH was also used to construct a model of PTH's interaction with the PTH1R TM region, where prominent interactions involve Ser1 and Lys13 of PTH and Met425 and Arg186 of the receptor [29].
PTH Binding (interaction) of PTH1R
3) Confidence 0.09 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The PTH1R acts as a common receptor for the Parathyroid hormone (PTH) and the Parathyroid hormone-related peptide (PTHrP) [1-3].
Parathyroid hormone Binding (receptor) of PTH1R in Parathyroid
4) Confidence 0.07 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.15 Pain Relevance 0.04
The PTH1R acts as a common receptor for the Parathyroid hormone (PTH) and the Parathyroid hormone-related peptide (PTHrP) [1-3].
PTH Binding (receptor) of PTH1R in Parathyroid
5) Confidence 0.07 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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