INT3098

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 28.27
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
plasma 3
PNS 3
myocardium 2
bone marrow 2
blood 2
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 3 100.00 Very High Very High Very High
Hippocampus 19 99.98 Very High Very High Very High
lidocaine 7 99.86 Very High Very High Very High
Neuritis 18 99.84 Very High Very High Very High
fibrosis 17 99.76 Very High Very High Very High
Peripheral nervous system 24 99.68 Very High Very High Very High
Inflammation 52 99.16 Very High Very High Very High
ischemia 185 98.92 Very High Very High Very High
Pain 13 98.32 Very High Very High Very High
headache 2 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 13 99.96 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.84 Very High Very High Very High
Fibrosis 13 99.76 Very High Very High Very High
Hypoxia 212 99.56 Very High Very High Very High
Erythrocytosis 7 99.48 Very High Very High Very High
Myocardial Infarction 148 99.40 Very High Very High Very High
Apoptosis 86 99.34 Very High Very High Very High
Anaemia 82 99.32 Very High Very High Very High
INFLAMMATION 57 99.16 Very High Very High Very High
Uremia 10 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis demonstrated that EPO was significantly increased in the PNS at the paralytic stage on day 14 post-immunization (PI); levels were significantly decreased at day 30 PI.
Positive_regulation (increased) of EPO in PNS associated with peripheral nervous system and immunization
1) Confidence 0.70 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 0.91 Pain Relevance 0.83
These findings suggest that EPO is transiently upregulated in EAN lesions and that the EPO/EPO-receptor binding pathway is associated with neuroprotection in EAN-affected PNS tissues.
Positive_regulation (upregulated) of EPO in PNS associated with peripheral nervous system and neuritis
2) Confidence 0.70 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 1.03 Pain Relevance 0.91
Upregulation of erythropoietin in rat peripheral nervous system with experimental autoimmune neuritis.
Positive_regulation (Upregulation) of erythropoietin in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis and neuritis
3) Confidence 0.70 Published 2010 Journal Brain Res. Section Title Doc Link 20361946 Disease Relevance 0.70 Pain Relevance 0.73
Thus, our data suggest the possibility that proliferation of progenitors in the penumbra was due to the selective increase of endogenous EPO in the penumbra in addition to the systemically administered r-Hu-EPO.
Positive_regulation (increase) of EPO
4) Confidence 0.69 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.39 Pain Relevance 0.06
In addition both Ki 67 and PCNA expression were significantly increased in EPO compared to GM-CSF treated animals in all post-operative days (p < 0.01).
Positive_regulation (increased) of EPO
5) Confidence 0.69 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.24 Pain Relevance 0.04
Erythropoietin level was not elevated.
Neg (not) Positive_regulation (elevated) of Erythropoietin
6) Confidence 0.68 Published 1988 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 3371213 Disease Relevance 1.00 Pain Relevance 0.14
The erythropoietin in serum was elevated (686 IU/microliters).
Positive_regulation (elevated) of erythropoietin
7) Confidence 0.68 Published 1990 Journal Rinsho Ketsueki Section Abstract Doc Link 2126822 Disease Relevance 1.27 Pain Relevance 0.13
After cessation of oxygen therapy, erythropoietin levels and the number of irreversibly sickled cells increased promptly, followed by an increase in the number of reticulocytes.
Positive_regulation (increased) of erythropoietin in reticulocytes
8) Confidence 0.68 Published 1984 Journal N. Engl. J. Med. Section Abstract Doc Link 6738642 Disease Relevance 0.40 Pain Relevance 0.07
A significant increase in serum erythropoietin (EPO) activity was demonstrated in one patient and was noticeable in another.
Positive_regulation (increase) of erythropoietin
9) Confidence 0.67 Published 1984 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6379677 Disease Relevance 0.33 Pain Relevance 0.09
A significant increase in serum erythropoietin (EPO) activity was demonstrated in one patient and was noticeable in another.
Positive_regulation (increase) of EPO
10) Confidence 0.67 Published 1984 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6379677 Disease Relevance 0.33 Pain Relevance 0.09
The anti-apoptotic protein Bcl-2 was significantly upregulated in EPO+G-CSF, EPO, and G-CSF groups, compared with control group (Fig. 4J), and the EPO+G-CSF combination induced significantly greater expression of Bcl-2 than EPO or G-CSF alone 24 hr after ischemia (Fig. 4J).
Positive_regulation (upregulated) of EPO associated with ischemia and apoptosis
11) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.43 Pain Relevance 0.20
To determine whether the administration of erythropoietin (EPO) early after the onset of ischemia could enhance the preservation of jeopardized myocardium by reperfusion, 236 patients admitted <6 hours after the onset of chest pain indicative of acute coronary syndromes confirmed to be ST-segment elevation acute myocardial infarctions who were treated with tenecteplase to induce coronary thrombolysis were studied.
Positive_regulation (administration) of EPO in myocardium associated with acute coronary syndrome, angina, ischemia and myocardial infarction
12) Confidence 0.50 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19801020 Disease Relevance 0.45 Pain Relevance 0.14
To determine whether the administration of erythropoietin (EPO) early after the onset of ischemia could enhance the preservation of jeopardized myocardium by reperfusion, 236 patients admitted <6 hours after the onset of chest pain indicative of acute coronary syndromes confirmed to be ST-segment elevation acute myocardial infarctions who were treated with tenecteplase to induce coronary thrombolysis were studied.
Positive_regulation (administration) of erythropoietin in myocardium associated with acute coronary syndrome, angina, ischemia and myocardial infarction
13) Confidence 0.50 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19801020 Disease Relevance 0.45 Pain Relevance 0.14
PCNA was increased in the EPO and GM-CSF+ EPO groups, while there was no increase in the GM-CSF group.


Positive_regulation (increased) of EPO
14) Confidence 0.50 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
One week after hepatectomy, hepatocytes showed increased expression of PCNA in all groups (p < 0.01), while Ki-67 was increased only in the EPO treatment group (p < 0.01).
Positive_regulation (increased) of EPO in hepatocytes
15) Confidence 0.50 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.06 Pain Relevance 0
We conclude that the combination of rHuEPO plus lidocaine is as effective as rHuEPO alone in increasing the hematocrit of rats with chronic renal failure.
Positive_regulation (effective) of rHuEPO associated with chronic renal failure and lidocaine
16) Confidence 0.49 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7947041 Disease Relevance 0.24 Pain Relevance 0.73
Although inefficient, we nevertheless conclude that an autologous blood collection program decreases homologous transfusion exposure and efforts should be directed to increase the erythropoietin response to the anemia produced by preoperative phlebotomy.
Positive_regulation (increase) of erythropoietin in blood associated with anaemia
17) Confidence 0.49 Published 1993 Journal J. Urol. Section Abstract Doc Link 8417219 Disease Relevance 0.47 Pain Relevance 0.13
The drug produced a significant decline in EPO at delivery time, but plasma EPO in the pups was unchanged.
Neg (unchanged) Positive_regulation (unchanged) of EPO in plasma
18) Confidence 0.47 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.13 Pain Relevance 0.14
CONCLUSIONS: While no significant differences in asphyxia markers were observed between the three groups, a tendency towards higher levels of EPO emerged in the buprenorphine-exposed group.


Positive_regulation (levels) of EPO
19) Confidence 0.47 Published 2008 Journal Acta Obstet Gynecol Scand Section Body Doc Link 18951215 Disease Relevance 0 Pain Relevance 0
Although the increase in our study is substantial, it is the result of a prolonged EPO pretreatment period (8 days).
Positive_regulation (result) of EPO
20) Confidence 0.46 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox