INT309888

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
cytoskeleton (FAAH) carbohydrate metabolic process (INS) cytoplasm (FAAH)
Anatomy Link Frequency
blood 2
INS (Homo sapiens)
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 35 94.64 High High
Inflammation 3 85.12 High High
Cannabinoid receptor 7 43.72 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Cannabinoid 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 137 99.70 Very High Very High Very High
Appetite Loss 1 92.72 High High
Diabetes Mellitus 29 87.00 High High
INFLAMMATION 3 85.12 High High
Insulin Resistance 4 55.92 Quite High
Disorder Of Lipid Metabolism 7 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Dyslipidemia /

Combined Dyslipidemia

1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous observations show that: 1) in nonobese, but not in obese, individuals, insulin negatively controls AEA more significantly than 2-AG blood levels [8], possibly by stimulating the expression of FAAH [6], which is more specific for AEA than 2-AG; and 2) circulating leptin levels are negatively associated with blood AEA, but not 2-AG, levels in lean, but not in obese, women with eating disorders [35], although leptin reduces both AEA and 2-AG levels in mouse adipocytes [3].
insulin Positive_regulation (stimulating) of Gene_expression (expression) of FAAH in blood associated with appetite loss and obesity
1) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.19 Pain Relevance 0.25

General Comments

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