INT309904

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ERBB2, TXK) nucleus (ERBB2, TXK) cytoplasm (ERBB2, TXK)
cell proliferation (ERBB2) signal transduction (ERBB2) DNA binding (TXK)
ERBB2 (Homo sapiens)
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 2 77.24 Quite High
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunotherapy Of Cancer 1 84.00 Quite High
Disease 8 82.00 Quite High
Lung Cancer 3 61.20 Quite High
Head & Neck Cancer 2 50.00 Quite Low
Solid Tumor 5 31.36 Quite Low
Recurrence 1 26.08 Quite Low
Cancer 16 10.24 Low Low
Toxicity 5 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since EGF-R and HER-2 heterodimerize to form functional signalling complexes, tyrosine-kinase inhibitors with dual specificity against HER-2 and EGF-R, such as lapatinib, have been investigated in phase I and II studies.
HER-2 Binding (heterodimerize) of tyrosine-kinase
1) Confidence 0.01 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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