INT309904

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.08

plasma membrane (ERBB2, TXK) nucleus (ERBB2, TXK) cytoplasm (ERBB2, TXK) cell proliferation (ERBB2) signal transduction (ERBB2) DNA binding (TXK)

ERBB2 (Homo sapiens) TXK (Homo sapiens)

Pain Link Frequency Relevance Heat methotrexate 2 77.24 palliative 1 5.00

Disease Link Frequency Relevance Heat Immunotherapy Of Cancer 1 84.00 Disease 8 82.00 Lung Cancer 3 61.20 Head & Neck Cancer 2 50.00 Solid Tumor 5 31.36 Recurrence 1 26.08 Cancer 16 10.24 Toxicity 5 5.00 Metastasis 4 5.00 Apoptosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since EGF-R and HER-2 heterodimerize to form functional signalling complexes, tyrosine-kinase inhibitors with dual specificity against HER-2 and EGF-R, such as lapatinib, have been investigated in phase I and II studies.

HER-2 Binding (heterodimerize) of tyrosine-kinase

1) Confidence 0.01 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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