INT309937

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.36
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il9) extracellular region (Il9)
Anatomy Link Frequency
mast cell 4
lung 1
eosinophils 1
basophils 1
Il9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 88 100.00 Very High Very High Very High
Inflammation 172 67.28 Quite High
fibrosis 3 32.52 Quite Low
chemokine 23 21.04 Low Low
corticosteroid 13 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 98.68 Very High Very High Very High
Asthma 378 97.84 Very High Very High Very High
Disease 80 93.60 High High
Hypersensitivity 49 87.16 High High
Mastocytosis 4 87.16 High High
Occupational Lung Diseases 70 87.12 High High
Schistosomiasis 4 84.28 Quite High
Sprains And Strains 20 78.24 Quite High
Worm Infection 6 77.68 Quite High
INFLAMMATION 176 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
8 mice/group)

Studies of mast cell accumulation in IL-9-deficient mice on a BALB/c background

Positive_regulation (accumulation) of IL-9 in mast cell
1) Confidence 0.49 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.20 Pain Relevance 0
Differences in the results from these studies may relate to differences in requirements for IL-9 in the mouse models used (i.e., transgenic, schistosoma antigen, acute vs chronic allergen exposure), and differences in requirements for IL-9 depending upon the mast cells quantitated (mast cell precursor vs mature mast cell), or differences in requirements for IL-9 depending upon the localization of the mast cell in the lung (mast cells precursors were quantitated from whole lung digests, whereas mature mast cells were quantitated in small, medium, and large airways).
Positive_regulation (requirements) of IL-9 in lung associated with targeted disruption
2) Confidence 0.49 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.55 Pain Relevance 0.06
Differences in the results from these studies may relate to differences in requirements for IL-9 in the mouse models used (i.e., transgenic, schistosoma antigen, acute vs chronic allergen exposure), and differences in requirements for IL-9 depending upon the mast cells quantitated (mast cell precursor vs mature mast cell), or differences in requirements for IL-9 depending upon the localization of the mast cell in the lung (mast cells precursors were quantitated from whole lung digests, whereas mature mast cells were quantitated in small, medium, and large airways).
Positive_regulation (requirements) of IL-9 in mast cells associated with targeted disruption
3) Confidence 0.49 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.47 Pain Relevance 0
Differences in the results from these studies may relate to differences in requirements for IL-9 in the mouse models used (i.e., transgenic, schistosoma antigen, acute vs chronic allergen exposure), and differences in requirements for IL-9 depending upon the mast cells quantitated (mast cell precursor vs mature mast cell), or differences in requirements for IL-9 depending upon the localization of the mast cell in the lung (mast cells precursors were quantitated from whole lung digests, whereas mature mast cells were quantitated in small, medium, and large airways).
Positive_regulation (requirements) of IL-9 in mast cell associated with targeted disruption
4) Confidence 0.49 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.50 Pain Relevance 0
TH2 cells have been regarded as a major source of IL-9 production [17].
Positive_regulation (source) of IL-9
5) Confidence 0.16 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.71 Pain Relevance 0.04
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-9 in basophils associated with cytokine
6) Confidence 0.07 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-9 in mast cells associated with cytokine
7) Confidence 0.02 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-9 in eosinophils associated with cytokine
8) Confidence 0.02 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13

General Comments

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