INT309940

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.79
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
nerve 1
epithelial cells 1
eosinophils 1
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 99.76 Very High Very High Very High
corticosteroid 6 47.52 Quite Low
chemokine 7 24.72 Low Low
cytokine 19 24.32 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 86 99.76 Very High Very High Very High
Hypersensitivity 14 99.36 Very High Very High Very High
Asthma 148 96.92 Very High Very High Very High
Rhinitis 14 96.68 Very High Very High Very High
Bronchitis 18 96.24 Very High Very High Very High
Disease 59 95.88 Very High Very High Very High
Occupational Lung Diseases 36 92.08 High High
Diphtheria 2 91.48 High High
Targeted Disruption 6 84.08 Quite High
Sprains And Strains 17 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this model, it was possible to show that the absence of eosinophils resulted in the abrogation of all of the pathophysiologic features of allergic airway inflammation, including ASM hyperreactivity and mucus hypersecretion.
Localization (hypersecretion) of ASM in eosinophils associated with inflammation and hypersensitivity
1) Confidence 0.21 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 1.03 Pain Relevance 0.15
Nonetheless, it is quite instructive to note that the localization of mast cells, in ASM cells or eosinophils, around cholinergic nerve fibres, in different phenotypes of eosinophilic airway diseases, may determine the relative role of each cell type in such conditions.


Localization (localization) of ASM in nerve associated with rhinitis and disease
2) Confidence 0.17 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 1.30 Pain Relevance 0.05
We treated A498 kidney epithelial cells with sphingomyelinase (SMase) for one hour, to release ceramide (r-ceramide) from the extracellular phosphocholine domain of sphingomyelin [32] (Figure 2A–D).
Localization (release) of SMase in epithelial cells
3) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.45 Pain Relevance 0

General Comments

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