INT309975

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Pygm) carbohydrate metabolic process (Pygm) cytoplasm (Pygm)
Anatomy Link Frequency
filaments 1
Pygm (Mus musculus)
Pkp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 44 5.00 Very Low Very Low Very Low
tetrodotoxin 8 5.00 Very Low Very Low Very Low
Nav1.6 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Nav1.1 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
nav1.3 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 44 94.92 High High
Malignant Neoplastic Disease 4 29.92 Quite Low
Cleidocranial Dysplasia 28 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 24 5.00 Very Low Very Low Very Low
Syndrome 20 5.00 Very Low Very Low Very Low
Cardiomyopathy 20 5.00 Very Low Very Low Very Low
Heart Arrhythmia 20 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 16 5.00 Very Low Very Low Very Low
Myocardial Infarction 16 5.00 Very Low Very Low Very Low
Heart Rate Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insertion of the intermediate filaments into the desmosomal complex requires desmoplakin (DP), a plaque protein that binds to intermediate filaments and to desmosomal proteins such as PKP2, PG, desmocollin, and desmoglein.
PG Binding (binds) of PKP2 in filaments
1) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.09 Pain Relevance 0
At the amino terminus of desmoplakin is a plakin domain that interacts with desmocollin, desmoglein, PKP2, and PG [36–38].
PG Binding (interacts) of PKP2
2) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
Although direct interactions have not been described between PKP2 and classic cadherins, PG interacts with both classic cadherins and PKP2 and may promote localization of PKP2 to the contact site even in the absence of desmosomal cadherins.
PG Binding (interacts) of PKP2
3) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.19 Pain Relevance 0
The ability of PG to bind to both classic and desmosomal cadherins and to interact with PKP2 may allow it to promote interactions of the two types of contacts both early in the formation of new intercalated disks as noted by Kostin et al. [25], and within the area composita later in the maturation of the disk [32].
PG Binding (interact) of PKP2
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.12 Pain Relevance 0

General Comments

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