INT31

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.30
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
shoulder 2
G cells 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 2 99.20 Very High Very High Very High
Pain 35 98.48 Very High Very High Very High
peptic ulcer disease 2 96.52 Very High Very High Very High
tetrodotoxin 1 96.32 Very High Very High Very High
abdominal pain 5 92.32 High High
spastic colon 14 88.52 High High
antagonist 7 87.08 High High
vagus nerve 1 83.80 Quite High
Analgesic 16 82.40 Quite High
Neuropeptide 8 80.52 Quite High
Disease Link Frequency Relevance Heat
Disease 36 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Cystadenocarcinoma 2 99.92 Very High Very High Very High
Pain 44 98.48 Very High Very High Very High
Ulcers 5 96.44 Very High Very High Very High
Gastritis 3 96.32 Very High Very High Very High
Diarrhoea 3 95.56 Very High Very High Very High
Syndrome 2 91.36 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 88.52 High High
Abdominal Pain 5 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally a decrease in gastrin serum levels was observed after the i.v. administration of Pirenzepine and this could be explained by a possible effect of blockade of this drug on the cholinergic receptors of the antral G cells, but these data need further experimental confirm.
Negative_regulation (decrease) of Gene_expression (levels) of gastrin in G cells
1) Confidence 0.42 Published 1982 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6957988 Disease Relevance 0.25 Pain Relevance 0.20
Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995.
Negative_regulation (inhibited) of Gene_expression (production) of Gastrin associated with cancer and somatostatin
2) Confidence 0.28 Published 1989 Journal Gastroenterology Section Abstract Doc Link 2473000 Disease Relevance 0.63 Pain Relevance 0.18
Serum gastrin levels were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of gastrin
3) Confidence 0.23 Published 1976 Journal N. Engl. J. Med. Section Abstract Doc Link 2870 Disease Relevance 0.21 Pain Relevance 0.11
The inclusion of PHI in the incubation medium decreased medium gastrin levels at all concentrations examined, an effect that was not altered by the addition of 10(-6) M tetrodotoxin to the medium.
Negative_regulation (decreased) of Gene_expression (levels) of gastrin associated with tetrodotoxin
4) Confidence 0.22 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2782406 Disease Relevance 0 Pain Relevance 0.10
In constipated patients fasting levels of gastrin and motilin and postprandial levels of gastrin, motilin and PP were decreased.
Negative_regulation (decreased) of Gene_expression (levels) of gastrin
5) Confidence 0.19 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.33 Pain Relevance 0.71
In constipated patients fasting levels of gastrin and motilin and postprandial levels of gastrin, motilin and PP were decreased.
Negative_regulation (decreased) of Gene_expression (levels) of gastrin
6) Confidence 0.19 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.33 Pain Relevance 0.72
Serum IgG, pepsinogen I, and gastrin levels were significantly decreased after treatment.
Negative_regulation (decreased) of Gene_expression (levels) of gastrin
7) Confidence 0.18 Published 1989 Journal Lancet Section Abstract Doc Link 2564507 Disease Relevance 0.33 Pain Relevance 0.08
Invasive GAS disease was defined as isolation of group A Streptococcus from a normally sterile
Negative_regulation (defined) of Gene_expression (disease) of GAS associated with disease
8) Confidence 0.13 Published 2008 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2612756 Disease Relevance 1.62 Pain Relevance 0.03
Given that the total amount of energy in the gas remains essentially the same (none is added or lost), as the pressure of the gas is reduced and volume increases the available energy can either be used to do the work of expansion, or to maintain the temperature of the gas, but it cannot be used for both.
Negative_regulation (reduced) of Gene_expression (pressure) of gas
9) Confidence 0.07 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2967548 Disease Relevance 0 Pain Relevance 0
Given that the total amount of energy in the gas remains essentially the same (none is added or lost), as the pressure of the gas is reduced and volume increases the available energy can either be used to do the work of expansion, or to maintain the temperature of the gas, but it cannot be used for both.
Negative_regulation (reduced) of Gene_expression (pressure) of gas
10) Confidence 0.07 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2967548 Disease Relevance 0 Pain Relevance 0
Hohlrieder et al. found that the worst pain after gynecological laparoscopic surgery was felt in the shoulder in 1% of the patients, two hours after surgery, but in 70% of the patients 24 hours after surgery.[4] Stanley et al. found that the pain attributed to intraperitoneal gas was as frequent as abdominal wall pain at 24 hours, but declined markedly by 48 hours, along with a corresponding reduction in the retained gas shown on X-ray.[5]

ANALGESIC DRUGS

Negative_regulation (reduction) of Gene_expression (retained) of gas in shoulder associated with pain
11) Confidence 0.02 Published 2009 Journal Saudi Journal of Anaesthesia Section Body Doc Link PMC2876935 Disease Relevance 0.79 Pain Relevance 1.23

General Comments

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