INT310006

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.77
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc30a4) transport (Slc30a4) cytoplasmic membrane-bounded vesicle (Slc30a4)
transmembrane transport (Slc30a4)
Anatomy Link Frequency
epithelium 2
intestinal villi 1
Slc30a4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 14 92.40 High High
agonist 7 30.80 Quite Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 161 99.92 Very High Very High Very High
Hepatitis 7 94.72 High High
Infection 329 90.60 High High
Targeted Disruption 14 77.80 Quite High
Disease 28 75.84 Quite High
Apoptosis 7 75.44 Quite High
Enteritis 7 73.56 Quite High
Stress 7 30.60 Quite Low
Adhesions 35 25.00 Low Low
Listeria Infections 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Without InlA, InlB does not provide adhesive strength for Lm to bind to the epithelium.
Lm Binding (bind) of in epithelium
1) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.17 Pain Relevance 0
As an evolutionary strategy, it is interesting that Lm targets junction remodeling and dynamin-dependent removal of E-cadherin from the cell surface as a mechanism of internalization rather than binding a more accessible, but more stable, apical receptor.
Lm Binding (binding) of
2) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.34 Pain Relevance 0
Since InlB increases the rate of Lm internalization through activation of c-Met at MCJs, we also wondered whether MCJs are intrinsically different in their endocytic activity as compared to the rest of the apical surface.
Lm Binding (internalization) of
3) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.52 Pain Relevance 0
We identified the cell extrusion zone at the tips of the intestinal villi as a novel site for gastrointestinal invasion where Lm uses InlA to bind E-cadherin for attachment and entry [30].
Lm Binding (bind) of in intestinal villi
4) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.37 Pain Relevance 0
The tRNAARG site-specific shuttle integration vectors pPL3 and pPL3e, which respectively confer chloramphenicol and erythromycin resistance to Listeria, and the L. monocytogenes (Lm) strain DH-L1039, which expresses sGFP under the control of the Hyper-SPO1 promoter fused to the 5?
Lm Binding (integration) of associated with sprains and strains
5) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.20 Pain Relevance 0
-herpesviruses bind Nectins, and Listeria monocytogenes (Lm) binds E-cadherin [7], [80]–[97].
Lm Binding (bind) of
6) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.09 Pain Relevance 0
As the dying cell is removed from the epithelium, the surrounding cells reorganize to form a multicellular junction (MCJ) that Lm exploits to find its basolateral receptor and invade.
Lm Binding (find) of in epithelium
7) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2869327 Disease Relevance 0.08 Pain Relevance 0.05

General Comments

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