INT310017

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Met) plasma membrane (Met) kinase activity (Met)
cytoplasm (Met)
Anatomy Link Frequency
hepatocytes 4
Met (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 46.96 Quite Low
cytokine 4 42.64 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 47 97.84 Very High Very High Very High
Targeted Disruption 26 76.64 Quite High
Sprains And Strains 25 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with cell kinetics data (Figure 1A), the early priming events appeared to be unaffected by the loss of c-Met signaling in hepatocytes consistent with the previous work demonstrating that the massive changes in gene expression in the first four hours after 2/3 PH, while preparing the quiescent hepatocytes to enter cell cycle, cannot predict whether DNA replication may actually occur [15].
Neg (unaffected) Regulation (unaffected) of Negative_regulation (loss) of c-Met in hepatocytes
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Regulation (effect) of Negative_regulation (downregulation) of c-Met in hepatocytes
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
inlB invasion, or alternately whether c-Met inhibition would selectively affect WT invasion.
Spec (whether) Regulation (affect) of Spec (whether) Negative_regulation (inhibition) of c-Met
3) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.61 Pain Relevance 0

General Comments

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