INT310069

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.32
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Mgll) lipid metabolic process (Mgll)
Anatomy Link Frequency
forebrain 2
Pain1 (Mus musculus)
Mgll (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
Inflammation 8 99.84 Very High Very High Very High
Endocannabinoid 25 99.50 Very High Very High Very High
Eae 5 99.16 Very High Very High Very High
addiction 1 94.64 High High
cINOD 3 92.96 High High
agonist 5 92.16 High High
Cannabinoid 15 91.68 High High
Lasting pain 1 71.28 Quite High
Antinociceptive 10 69.44 Quite High
Disease Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
INFLAMMATION 8 99.84 Very High Very High Very High
Neuropathic Pain 32 99.16 Very High Very High Very High
Cognitive Disorder 1 95.40 Very High Very High Very High
Nociception 13 84.08 Quite High
Disease 3 80.68 Quite High
Toxicity 7 77.52 Quite High
Nervous System Injury 34 63.92 Quite High
Urological Neuroanatomy 1 50.72 Quite High
Syndrome 1 49.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has been shown that inhibition of endocannabinoid metabolism via specific inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) reduces pain in inflammatory and neuropathic pain models [11], [12], without producing diverse side effects, such as temporary memory impairment, addiction and psychotropic effects, which are associated with agonists at cannabinoid-1 (CB1) receptors in forebrain circuits.
Negative_regulation (inhibition) of pain Positive_regulation (reduces) of MAGL in forebrain associated with addiction, pain, endocannabinoid, cognitive disorder, inflammation, cannabinoid, eae and agonist
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.32 Pain Relevance 1.23

General Comments

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