INT31008

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 1999
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 2.31
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, Pomc) extracellular space (Crh, Pomc) extracellular region (Crh, Pomc)
cell-cell signaling (Pomc) response to stress (Crh) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
cerebrospinal fluid 2
hypothalamus 1
Crh (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 2 100.00 Very High Very High Very High
cva 22 96.00 Very High Very High Very High
antagonist 1 88.12 High High
ischemia 2 87.88 High High
Opioid 1 86.00 High High
Endogenous opioid 2 83.24 Quite High
Neuropeptide 2 75.00 Quite High
anesthesia 1 74.56 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 12 97.32 Very High Very High Very High
Cv General 4 Under Development 24 96.52 Very High Very High Very High
Vascular Disease 2 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro).
corticotropin-releasing factor Positive_regulation (Stimulation) of beta-endorphin associated with dynorphin
1) Confidence 0.49 Published 1986 Journal Brain Res. Section Title Doc Link 2879612 Disease Relevance 0 Pain Relevance 0.23
Corticotropin releasing hormone (CRH) increases beta-endorphin (beta-end like) concentration in cerebrospinal fluid of rats with vasospasm following subarachnoid hemorrhage.
Corticotropin releasing hormone Positive_regulation (increases) of beta-endorphin in cerebrospinal fluid associated with cv general 4 under development, cva and increased venous pressure under development
2) Confidence 0.21 Published 1999 Journal J. Physiol. Pharmacol. Section Title Doc Link 10574471 Disease Relevance 1.15 Pain Relevance 0.45
Corticotropin releasing hormone (CRH) increases beta-endorphin (beta-end like) concentration in cerebrospinal fluid of rats with vasospasm following subarachnoid hemorrhage.
CRH Positive_regulation (increases) of beta-endorphin in cerebrospinal fluid associated with cv general 4 under development, cva and increased venous pressure under development
3) Confidence 0.21 Published 1999 Journal J. Physiol. Pharmacol. Section Title Doc Link 10574471 Disease Relevance 1.15 Pain Relevance 0.45
These results Indicate that the central administration of NPY increases the CRF mRNA levels in the hypothalamus and the probable CRF release, which increases the proopiomelanocortin mRNA levels and ACTH secretion in the anterior pituitary.
CRF Positive_regulation (increases) of proopiomelanocortin mRNA in hypothalamus
4) Confidence 0.15 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8392133 Disease Relevance 0 Pain Relevance 0.14

General Comments

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