INT310097

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.28 Pain Relevance 0.18

cell differentiation (H1fnt) chromosome (H1fnt) nucleus (H1fnt) DNA binding (H1fnt)

Anatomy Link Frequency T cells 1 H1fnt (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 1 65.20 Inflammation 1 63.76 Paracetamol 2 62.44 headache 9 50.64 alcohol 1 43.84 imagery 1 38.44 cytokine 8 20.40 drug abuse 1 17.28 Analgesic 8 5.00 depression 4 5.00

Disease Link Frequency Relevance Heat Influenza Virus Infection 282 100.00 Thrombocytopenia 1 82.00 Lymphopenia 1 75.76 Fever 36 75.60 Pressure Volume 2 Under Development 1 69.76 Hypoxia 1 68.40 INFLAMMATION 1 63.76 Sprains And Strains 93 53.56 Cough 5 52.88 Chills 3 52.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Clinical presentation of patients who tested positive for 2009 pandemic influenza A (H1N1) virus

Positive_regulation (tested) of H1N1 associated with influenza virus infection

1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871038 Disease Relevance 1.74 Pain Relevance 0.18

The studies included HAI testing based on guidance from the US FDA for consistency with inactivated H1N1 vaccine studies.

Positive_regulation (inactivated) of H1N1

2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.17 Pain Relevance 0

These studies were designed to rapidly provide the US FDA with sufficient information to guide licensure decisions regarding MedImmune's monovalent live attenuated 2009 H1N1 vaccine in the setting of a widespread H1N1 pandemic; as a result they have a number of limitations.

Positive_regulation (vaccine) of H1N1

3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.32 Pain Relevance 0

Using the homologous stimulant, H1N1/CA antigen, induction of about 0.25% of CD4 T cells by the live vectors was achieved.

Positive_regulation (induction) of H1N1 in T cells

4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.06 Pain Relevance 0

With the Brisbane (H1N1/BR) and with the H5N1/VN antigens, good levels of cross reactivity were seen, while the New Caledonia H1N1 antigen (H1N1/NC) was a poor stimulant (Fig. 5A).

Positive_regulation (stimulant) of H1N1

5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.