INT310164

Context Info Confidence 0.40 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 6.11 Pain Relevance 1.17

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Anatomy Link Frequency chondrocyte 2 colon 2 Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 637 98.94 cytokine 35 5.00 metalloproteinase 22 5.00 fibrosis 15 5.00 Inflammation 9 5.00 Pain 7 5.00 Arthritis 7 5.00 palliative 1 5.00 Immobilon 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Disease 91 99.54 Osteoarthritis 672 98.94 Cancer 99 98.60 Colon Cancer 7 98.24 Aging 115 98.08 Prostate Cancer 6 94.52 Breast Cancer 3 93.32 Metastasis 15 88.48 Recurrence 2 85.24 Melanoma 5 82.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RI/ALK5 pathway and ALK5 inhibition prevents radiation-induced suppression of migration and sprouting

Negative_regulation (inhibition) of Gene_expression (pathway) of ALK5

1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.11 Pain Relevance 0

Moreover, in two experimental models of OA - the DMM (meniscus destabilization) model and STR/ORT mice (spontaneous OA) - development of the disease was correlated with a loss of ALK5 expression.

Negative_regulation (loss) of Gene_expression (expression) of ALK5 associated with disease and osteoarthritis

2) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.86 Pain Relevance 0.25

Blocking ALK5 expression using siRNA resulted in elevated expression of MMP-13 [85].

Negative_regulation (Blocking) of Gene_expression (expression) of ALK5

3) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.30 Pain Relevance 0.08

We postulate that the loss of ALK5 expression and the concomitant elevated ratio of ALK1/ALK5 will have profound effects on chondrocyte behavior.

Negative_regulation (loss) of Gene_expression (expression) of ALK5 in chondrocyte

4) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.74 Pain Relevance 0.22

is reduced - and this is associated with a loss in ALK5 expression, and TGF?

Negative_regulation (loss) of Gene_expression (expression) of ALK5

5) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06

In old animals, showing a decrease in the ALK5/ALK1 ratio, the protective effect of TGF?

Negative_regulation (decrease) of Gene_expression (ratio) of ALK5

6) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.63 Pain Relevance 0.19

A prevailing expression of ALK5 will result in a dominance of the Smad2/3 signaling route, while ALK1 dominance will result in a stronger Smad1/5/8 pathway.

Negative_regulation (prevailing) of Gene_expression (expression) of ALK5

7) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.56 Pain Relevance 0.18

In old animals, showing a decrease in the ALK5/ALK1 ratio, the protective effect of TGF?

Negative_regulation (effect) of Gene_expression (ratio) of ALK5

8) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.64 Pain Relevance 0.19

Reduced ALK-5 and TGFBR2 expression correlates with a shorter survival rate of colon cancer patients, as does reduced expression of the coreceptor betaglycan in breast and prostate cancer patients [48–50].

Negative_regulation (Reduced) of Gene_expression (expression) of ALK-5 in colon associated with colon cancer and prostate cancer

9) Confidence 0.07 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.01 Pain Relevance 0

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