INT310167

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 5.47
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Acvrl1) kinase activity (Acvrl1)
Anatomy Link Frequency
chondrocytes 5
cartilage 2
Acvrl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 819 98.96 Very High Very High Very High
cytokine 45 5.00 Very Low Very Low Very Low
metalloproteinase 27 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 864 98.96 Very High Very High Very High
Leukemia 10 97.04 Very High Very High Very High
Myeloid Leukemia 6 96.08 Very High Very High Very High
Aging 117 94.96 High High
Disease 120 92.96 High High
Syndrome 28 88.44 High High
Rupture 2 85.88 High High
Brain Hemorrhage 2 67.32 Quite High
Cleidocranial Dysplasia 2 64.96 Quite High
Brain Stem Infarctions 2 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the ratio of ALK1/ALK5 expressing cells strongly increased in OA articular chondrocytes.
Gene_expression (expressing) of ALK1 in chondrocytes associated with osteoarthritis
1) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.87 Pain Relevance 0.26
Noticeably, human osteoarthritic cartilage demonstrated a significant correlation between ALK1 and MMP-13 mRNA expression and a trend (P = 0.05 to 0.1) with type II collagen and aggrecan expression.
Gene_expression (expression) of ALK1 in cartilage associated with osteoarthritis
2) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.30 Pain Relevance 0.07
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Gene_expression (expression) of ALK1
3) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.25 Pain Relevance 0.06
on chondrocytes will be determined by the relative expression of ALK5 and ALK1.
Spec (determined) Gene_expression (expression) of ALK1 in chondrocytes
4) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.50 Pain Relevance 0.14
We have observed that the chondrocytes in the deep zone, just above the tidemark, show high ALK1 expression (personal observation).
Gene_expression (expression) of ALK1 in chondrocytes
5) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.57 Pain Relevance 0.18
The ALK1 (Smad1/5/8) and ALK5 (Smad3) signaling balance in chondrocytes apparently determines MMP-13 expression.
Gene_expression (/) of ALK1 in chondrocytes
6) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06
In old animals, showing a decrease in the ALK5/ALK1 ratio, the protective effect of TGF?
Gene_expression (ratio) of ALK1
7) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.63 Pain Relevance 0.19
Notably, signaling via ALK5 (Smad2/3 route) results in markedly different chondrocyte responses than ALK1 signaling (Smad1/5/8), and we postulate that the balance between ALK5 and ALK1 expression on chondrocytes will determine the overall effect of TGF?
Gene_expression (expression) of ALK1 in chondrocytes
8) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875624 Disease Relevance 0.52 Pain Relevance 0.22
Moreover, human OA cartilage showed a significant correlation between ALK1 and MMP-13 expression.
Gene_expression (expression) of ALK1 in cartilage associated with osteoarthritis
9) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875624 Disease Relevance 0.54 Pain Relevance 0.23
receptors, which have been investigated most thoroughly, are ubiquitously expressed ALK-5 and endothel-specific ALK-1.
Gene_expression (expressed) of endothel-specific ALK-1
10) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.60 Pain Relevance 0
Our group investigated expression of ALK-1 and ALK-5 in various leukemic cells lines and samples from patients with acute myeloid leukemia (AML).
Spec (investigated) Gene_expression (expression) of ALK-1 associated with leukemia and myeloid leukemia
11) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.43 Pain Relevance 0

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