INT310174

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.16
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Smad1) nucleus (Smad1) intracellular (Smad1)
cytoplasm (Smad1)
Anatomy Link Frequency
chondrocyte 2
growth plate 1
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 273 97.96 Very High Very High Very High
fibrosis 15 82.24 Quite High
Inflammatory response 1 11.56 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 15 98.24 Very High Very High Very High
Osteoarthritis 288 97.96 Very High Very High Very High
Disease 51 97.52 Very High Very High Very High
Apoptosis 26 96.64 Very High Very High Very High
Autism 148 90.40 High High
Aging 39 85.84 High High
Fibrosis 21 82.24 Quite High
Liver Cancer 4 81.16 Quite High
Targeted Disruption 9 80.52 Quite High
Syndrome 28 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
receptor, which then activates the SMAD family of transcriptional regulators.
Positive_regulation (activates) of SMAD family
1) Confidence 0.45 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.67 Pain Relevance 0
SB431542 both reduced pSMAD2 and increased pSMAD1, suggesting a sophisticated signaling mechanism for this compound.


Positive_regulation (increased) of pSMAD1
2) Confidence 0.38 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.14 Pain Relevance 0.04
Specifically, ALK-4/5/7 inhibition led to increases in pSMAD1 levels and BMP-2 treatment led to a reduction in pSMAD2 levels (Figure 1).
Positive_regulation (increases) of pSMAD1
3) Confidence 0.38 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
They showed that SB431542 enhanced the effects of BMP-2 on osteogenesis and that this was associated with increased SMAD1 signaling and decreased SMAD2 signaling.
Positive_regulation (increased) of SMAD1
4) Confidence 0.31 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Activation of the Smad1/5/8 route in chondrocytes is strongly associated with chondrocyte terminal differentiation and hypertrophy [62].
Positive_regulation (Activation) of Smad1 in chondrocyte associated with hypertrophy
5) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.43 Pain Relevance 0.05
Bone morphogenetic protein itself or activation of the bone morphogenetic protein pathway (Smad1/5/8) leads, both in the growth plate and in articular chondrocytes, to expression of terminal differentiation markers [63-65].
Positive_regulation (activation) of Smad1 in growth plate
6) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.43 Pain Relevance 0.05
The latter observation shows not only that activation of the Smad1/5/8 route leads to terminal differentiation but also that loss of Smad2/3 can lead to induction of chondrocyte terminal differentiation.
Positive_regulation (activation) of Smad1 in chondrocyte
7) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.23 Pain Relevance 0
Interestingly, both pathways signal via activation of SMAD-1, -5, and -8 although these SMADs have been described as characteristic BMP downstream signals [71].
Positive_regulation (activation) of SMAD-1
8) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0
This opposing effect was thought to be mediated by activation of SMAD-1/5/8 by ALK-1 and SMAD-2/3 by ALK-5 [68].
Positive_regulation (activation) of SMAD-1
9) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.26 Pain Relevance 0

General Comments

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