INT310176

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.83 Pain Relevance 0

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Glioma 4 89.80 Anaplastic Astrocytoma 1 87.72 Non-small-cell Lung Cancer 1 76.56 Cancer 55 73.68 Melanoma 5 60.00 Metastasis 12 59.28 Osteolysis 1 47.92 Lymphatic System Cancer 1 41.56 Carcinoma 4 26.56 Hepatocellular Cancer 3 25.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

receptors were almost exclusively targeted at ALK-5, in most cases using small molecule inhibitors such as SB431542 which showed similar results in several in vitro and in vivo studies.

Localization (targeted) of ALK-5

1) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.83 Pain Relevance 0

General Comments

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