INT310179

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Syndrome 14 49.80 Rupture 1 47.24 Brain Hemorrhage 1 28.68 Cleidocranial Dysplasia 1 26.32 Disease 6 25.20 Brain Stem Infarctions 1 23.84 Cancer 55 5.00 Metastasis 12 5.00 Colon Cancer 7 5.00 Prostate Cancer 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Goumans et al. revealed that the inhibitor of DNA binding 1 (ID-1), a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors, is a specific downstream signal of ALK-1, whereas the proteinase inhibitor plasminogen activator inhibitor-1 (PAI-1) is induced by ALK-5 activation [68].

Positive_regulation (induced) of Positive_regulation (activation) of ALK-5

1) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0

General Comments

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