INT310192

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

signal transduction (Tgfbr1, Acvrl1) kinase activity (Tgfbr1, Acvrl1) cell differentiation (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1)

Tgfbr1 (Mus musculus) Acvrl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Leukemia 5 24.24 Cancer 55 5.00 Syndrome 14 5.00 Metastasis 12 5.00 Colon Cancer 7 5.00 Prostate Cancer 6 5.00 Disease 6 5.00 Melanoma 5 5.00 Carcinoma 4 5.00 Glioma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Shao et al. demonstrated that ALK-1 and ALK-5 are both essential for the regulation of vascular endothelial growth factor (VEGF), which is believed to be the central growth factor in angiogenesis.

ALK-5 Positive_regulation (essential) of Regulation (regulation) of ALK-1

1) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0

General Comments

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