INT310229

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS, SUCLA2) mitochondrion (SUCLA2) extracellular space (INS)
extracellular region (INS) carbohydrate metabolic process (INS) ligase activity (SUCLA2)
Anatomy Link Frequency
pericytes 1
INS (Homo sapiens)
SUCLA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 45 98.08 Very High Very High Very High
Death 35 93.68 High High
Disease 135 88.24 High High
Cognitive Disorder 5 87.48 High High
Diabetes Mellitus 35 85.76 High High
Neuroblastoma 35 82.88 Quite High
Insulin Resistance 20 75.80 Quite High
Neurodegenerative Disease 15 67.44 Quite High
Apoptosis 125 65.16 Quite High
Dementia 10 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies indicate that insulin, interacting with A-beta, inhibits its fibrillar growth as shown in a cell-free assay and in the cell surface of human brain pericytes [10] reducing the A-beta toxic effect.
insulin Binding (interacting) of A-beta in pericytes
1) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.78 Pain Relevance 0
Experimental data [12] have demonstrated that A-beta competes for binding of insulin to its receptor.
insulin Binding (binding) of A-beta
2) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.21 Pain Relevance 0
However, it is not understood if this effect was originated through the binding of A-beta to insulin or directly to the insulin receptor.
insulin Binding (binding) of A-beta
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.04 Pain Relevance 0
The authors suggest that the link between A-beta and insulin is associated to the impairment of glucose utilization, and in agreement to this hypothesis, a recovery of cell viability, through insulin administration could be due to the retrieval of normal glucose metabolism.
insulin Binding (associated) of A-beta
4) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.61 Pain Relevance 0
However, it is not understood if this effect was originated through the binding of A-beta to insulin or directly to the insulin receptor.
insulin Binding (binding) of A-beta
5) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.04 Pain Relevance 0

General Comments

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