INT310250

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.68 Pain Relevance 0.37

signal transduction (TLE1) nucleus (TLE1) transcription factor binding (TLE1)

Anatomy Link Frequency brain 1 TLE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Cannabinoid 37 99.40 agonist 25 75.88 antagonist 12 73.60 Glutamate 26 53.72 Neurotransmitter 1 25.16 Action potential 7 5.00 Hippocampus 5 5.00 GABAergic 5 5.00 gABA 4 5.00 tetrodotoxin 2 5.00

Disease Link Frequency Relevance Heat Epilepsy 51 100.00 Sclerosis 4 92.32 Convulsion 34 71.68 Recurrence 1 71.20 Status Epilepticus 37 15.56 Gliosis 2 5.00 Neurological Disease 1 5.00 Primary Sclerosing Cholangitis 1 5.00 Myoclonus 1 5.00 Disseminated Intravascular Coagulation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, further study is needed to understand the interactions between cannabinoids and other receptor targets as well as cannabinoid effects in other brain areas affected in TLE or in other TLE models, where axon sprouting may be significant but not as robust as in the pilocarpine-treated mouse.

Regulation (affected) of TLE in brain associated with epilepsy and cannabinoid

1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.68 Pain Relevance 0.37

General Comments

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