INT310292

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 4.13
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Serpina10)
Anatomy Link Frequency
plasma 2
lung 2
colon 1
Serpina10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 143 93.92 High High
Inflammation 55 93.60 High High
cva 11 85.36 High High
Paracetamol 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 22 99.56 Very High Very High Very High
Stress 11 99.32 Very High Very High Very High
Shock 154 98.76 Very High Very High Very High
Apoptosis 22 98.48 Very High Very High Very High
Necrosis 22 95.56 Very High Very High Very High
Cancer 22 95.20 Very High Very High Very High
Injury 66 95.16 Very High Very High Very High
Pneumonia 11 93.60 High High
INFLAMMATION 44 91.12 High High
Ulcers 11 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, PZ is reported to induce HSP70 (HSP72) in rat gastric mucosa, mouse colonic mucosa, human colon cells and mouse hepatocytes, and protect against injuries induced by a variety of stimuli [16–19, 42].
Gene_expression (induce) of PZ in colon associated with injury
1) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.53 Pain Relevance 0.16
Pretreatment of mice with PZ inhibited LPS-mediated TNF-?
Gene_expression (Pretreatment) of PZ
2) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.30 Pain Relevance 0.08
PZ, zinc sulfate or Car at concentrations of 50 or 100 µM was added into the medium 6 or 2 h before LPS administration.


Gene_expression (administration) of PZ
3) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.07 Pain Relevance 0
In conclusion, the present study has shown that PZ protects against LPS-induced endotoxin shock via inhibition of NF-?
Gene_expression (protects) of PZ associated with shock
4) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.36 Pain Relevance 0.04
Effect of PZ pretreatment on plasma NO levels in mice after LPS administration
Gene_expression (pretreatment) of PZ in plasma
5) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.12 Pain Relevance 0.03
Effect of PZ pretreatment on lung histology in mice after LPS administration
Gene_expression (pretreatment) of PZ in lung
6) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.26 Pain Relevance 0.09
Pretreatment of RAW264 cells with PZ suppressed the production of NO and TNF-?
Gene_expression (Pretreatment) of PZ
7) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2872229 Disease Relevance 0.80 Pain Relevance 0.04
Effect of PZ pretreatment on plasma TNF-?
Gene_expression (pretreatment) of PZ in plasma
8) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.25 Pain Relevance 0.07
levels in endotoxin shock mice after peritoneal injection of lipopolysaccharide (LPS), and how PZ protects against LPS-induced endotoxin shock.
Gene_expression (protects) of PZ associated with shock
9) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2872229 Disease Relevance 0.80 Pain Relevance 0.05
Although serum zinc level in mice treated with PZ at 1 h before LPS was higher than that in 2-h treatment of mice with PZ (see Fig. 1), treatment with PZ at 2 h before LPS improved the survival rate better than 1-h treatment with PZ.
Gene_expression (see) of PZ
10) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.08 Pain Relevance 0
However, PZ did not enhance LPS-mediated HSP70 protein expression in the mouse lung.
Gene_expression (expression) of PZ in lung
11) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.57 Pain Relevance 0.12

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