INT310348

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) plasma membrane (Gabrd)
response to stress (Tspo)
Anatomy Link Frequency
cortex 1
Tspo (Rattus norvegicus)
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 384 98.52 Very High Very High Very High
Dopamine 24 62.56 Quite High
GABA receptor 2 59.44 Quite High
gABA 10 46.72 Quite Low
Hippocampus 2 43.52 Quite Low
Serotonin 38 42.12 Quite Low
Raphe 4 37.00 Quite Low
addiction 16 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 34 89.28 High High
Stress 68 21.12 Low Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low
Aggression 10 5.00 Very Low Very Low Very Low
Alcohol Addiction 6 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vitro binding affinity of flunitrazepam was increased in the cortex of isolated and contact-housed Wistar rats compared to group-housed rats, indicating that the GABAA receptor may be more potently activated by binding at the benzodiazepine site in isolated rats, although there were no differences in binding affinity as an effect of alcohol intake [42].
benzodiazepine site Binding (binding) of GABAA in cortex associated with alcohol
1) Confidence 0.00 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872279 Disease Relevance 0.21 Pain Relevance 0.40
There is evidence that GABAA receptor subunit composition changes following isolation [43], which could contribute to the differential binding affinity at the benzodiazepine site, while the altered concentrations of neuroactive steroids that may act as allosteric modulators mentioned above may also affect binding affinity [42].
benzodiazepine site Binding (affinity) of GABAA
2) Confidence 0.00 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872279 Disease Relevance 0.22 Pain Relevance 0.48

General Comments

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