INT310379

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 93 82.28 Quite High
addiction 2 74.32 Quite High
headache 1 59.92 Quite High
Glutamate 1 14.00 Low Low
depression 3 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 12 99.92 Very High Very High Very High
Parkinson's Disease 2 99.32 Very High Very High Very High
Toxicity 4 94.72 High High
Cv Unclassified Under Development 11 94.36 High High
Alcohol Addiction 24 88.16 High High
Disease 13 85.68 High High
Heart Rate Under Development 2 60.48 Quite High
Headache 1 59.92 Quite High
Vomiting 1 59.52 Quite High
Increased Venous Pressure Under Development 5 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data further revealed that enhanced activation of Akt and AMPK, and subsequently, inhibition of Foxo3, apoptosis, and mitochondrial dysfunction may play a pivotal role in ALDH2 overexpression-induced cardioprotection against ethanol toxicity [130].
Negative_regulation (inhibition) of Foxo3 associated with parkinson's disease, toxicity and apoptosis
1) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 1.28 Pain Relevance 0.32
Further, immunoblot analysis of total cell lysates for phospho-FOXO3a revealed that phospho-FOXO3a at Ser318 was decreased significantly more than at Ser253.
Negative_regulation (decreased) of FOXO3a
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0

General Comments

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