INT310381

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.19
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nrxn3)
Anatomy Link Frequency
globus pallidus 4
Nrxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 28 100.00 Very High Very High Very High
cocaine 2 100.00 Very High Very High Very High
Nicotine 2 100.00 Very High Very High Very High
drug abuse 2 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Neurotransmitter 6 95.36 Very High Very High Very High
Nucleus accumbens 6 87.44 High High
tolerance 14 62.56 Quite High
Peripheral nervous system 2 8.16 Low Low
Analgesic 2 6.56 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 2 100.00 Very High Very High Very High
Opiate Addiction 2 100.00 Very High Very High Very High
Drug Dependence 2 100.00 Very High Very High Very High
Adhesions 8 84.48 Quite High
Alcohol Addiction 50 50.00 Quite Low
Substance Withdrawal Syndrome 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pituitary Cancer 2 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene for one of the neurexin family proteins, neurexin-3, is associated with nicotine dependence [139,140], opioid dependence [141], and poly-substance abuse [142], and cocaine exposure increases neurexin-3 expression in the globus pallidus of mice [143].
Positive_regulation (increases) of Gene_expression (expression) of neurexin-3 in globus pallidus associated with addiction, drug abuse, nicotine, opioid and cocaine
1) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.58 Pain Relevance 0.49
The gene for one of the neurexin family proteins, neurexin-3, is associated with nicotine dependence [139,140], opioid dependence [141], and poly-substance abuse [142], and cocaine exposure increases neurexin-3 expression in the globus pallidus of mice [143].
Positive_regulation (increases) of Gene_expression (expression) of neurexin-3 in globus pallidus associated with addiction, drug abuse, nicotine, opioid and cocaine
2) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.61 Pain Relevance 0.51

General Comments

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