INT3104

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Context Info
Confidence 0.54
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 76
Total Number 76
Disease Relevance 29.81
Pain Relevance 12.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
follicle 8
plasma 7
pituitary 4
blood 2
sperm 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 4 99.84 Very High Very High Very High
Morphine 12 99.68 Very High Very High Very High
antagonist 42 99.50 Very High Very High Very High
Endogenous opioid 5 99.42 Very High Very High Very High
narcan 29 99.40 Very High Very High Very High
Clonidine 15 98.40 Very High Very High Very High
epidural 4 98.36 Very High Very High Very High
tetrodotoxin 8 98.08 Very High Very High Very High
analgesia 5 98.00 Very High Very High Very High
agonist 22 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 16 100.00 Very High Very High Very High
Hypopituitarism 12 100.00 Very High Very High Very High
Pituitary Cancer 16 99.96 Very High Very High Very High
Residual Neoplasm 1 99.82 Very High Very High Very High
Autoimmune Disease 3 99.68 Very High Very High Very High
Reprotox - General 1 113 99.34 Very High Very High Very High
Growth Hormone Deficiency 2 99.32 Very High Very High Very High
Vomiting 8 99.20 Very High Very High Very High
Galactorrhea 13 99.08 Very High Very High Very High
Precocious Puberty 10 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that acute morphine administration decreases luteinizing hormone (LH) plasma levels and this is due to an inhibitory modulation on gonadotrophin releasing hormone discharge from the hypothalamic neurons.
Negative_regulation (decreases) of luteinizing hormone in neurons associated with morphine
1) Confidence 0.54 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276950 Disease Relevance 0.17 Pain Relevance 0.45
In 9 cases treated with PG, the method proved to be successful in 89%, as indicated by reduction of human chorionic gonadotropin (hCG) serum values to less than 20 IU/l.
Negative_regulation (reduction) of hCG
2) Confidence 0.54 Published 1992 Journal Cesk Gynekol Section Abstract Doc Link 1385760 Disease Relevance 0.24 Pain Relevance 0.08
In 34 women missed miscarriage was diagnosed readily by ultrasound; all but five had depressed hCG and PAPP-A levels.
Negative_regulation (depressed) of hCG associated with reprotox - general 1
3) Confidence 0.47 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.54 Pain Relevance 0.07
In 10 women the serum concentration of human chorionic gonadotrophin (HCG) decreased to less than 20 IU/l in a median time of 7.5 days, the range being 1-46 days.
Negative_regulation (decreased) of HCG
4) Confidence 0.43 Published 1989 Journal Hum. Reprod. Section Abstract Doc Link 2745677 Disease Relevance 0.25 Pain Relevance 0.08
Serum alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) level were at 51ng/ml and 31IU/l when total dose of 2,000 rads were over, and they decreased to 3ng/ml and 6.6IU/l at the dose of 4,225 rads respectively.
Negative_regulation (decreased) of HCG
5) Confidence 0.43 Published 1985 Journal No Shinkei Geka Section Abstract Doc Link 4047321 Disease Relevance 0.92 Pain Relevance 0.15
Co-treatment with GH was associated with a reduction of approximately 30% in gonadotrophin requirement.
Negative_regulation (reduction) of gonadotrophin
6) Confidence 0.41 Published 1994 Journal Hum. Reprod. Section Abstract Doc Link 8027274 Disease Relevance 0.08 Pain Relevance 0.45
Serum hCG and progesterone were determined by radioimmunoassay technique in 31 cases, and it was found that the hCG and progesterone levels both declined rapidly at 12 hours and fell to 35.5% and 46.4% respectively 24 hours after injection.
Negative_regulation (declined) of hCG
7) Confidence 0.40 Published 1984 Journal Shengzhi Yu Biyun Section Abstract Doc Link 12267336 Disease Relevance 0.75 Pain Relevance 0.17
In 8 women the serum concentration of beta hCG decreased to less than 20 IU/l in a mean time of 12.3 days.
Negative_regulation (decreased) of hCG
8) Confidence 0.40 Published 1992 Journal Cesk Gynekol Section Abstract Doc Link 1385760 Disease Relevance 0.25 Pain Relevance 0.09
The primary outcome measure is an uneventful decline of serum hCG to an undetectable level (< 2 IU/l) by the initial intervention strategy, i.e. expectant management or a single dose systemic MTX.


Negative_regulation (decline) of hCG associated with methotrexate
9) Confidence 0.39 Published 2008 Journal BMC Womens Health Section Body Doc Link PMC2453103 Disease Relevance 0.30 Pain Relevance 0.36
Levonorgestrel prevents pregnancy by decreasing luteinizing hormone and follicle stimulating hormone which prevents ovulation, reducing the rate of ovum transfer in the tube, making the endometrium incompatible for implantation, and making the cervical mucus too thick and scanty for sperms to migrate if ovulation does occur. 1-year pregnancy rates for Norplant users are much lower than for women who use other contraceptives (0.6/100 users vs. 2.3/100 for OC users and 2.4/100 for IUD users).
Negative_regulation (decreasing) of luteinizing hormone in follicle
10) Confidence 0.39 Published 1992 Journal Nurse Pract Section Abstract Doc Link 1565306 Disease Relevance 0.16 Pain Relevance 0.09
Following postoperative craniospinal irradiation (whole brain, 30Gy; local, 18Gy; spinal canal 28Gy), CT scans showed no residual tumor and the HCG levels decreased until they were undetectable.
Negative_regulation (decreased) of HCG in canal associated with residual neoplasm
11) Confidence 0.38 Published 1991 Journal No Shinkei Geka Section Abstract Doc Link 1891059 Disease Relevance 0.82 Pain Relevance 0.09
The mean resolution time for reduction of beta-HCG concentrations was 23.5 days (range 7-40).
Negative_regulation (reduction) of beta-HCG
12) Confidence 0.38 Published 1996 Journal Hum. Reprod. Section Abstract Doc Link 8671235 Disease Relevance 0.52 Pain Relevance 0.28
However, 18% of these successful cases had a slow decline in HCG, indicating incomplete expulsion of viable chorionic tissue.
Negative_regulation (decline) of HCG
13) Confidence 0.38 Published 1978 Journal Contraception Section Abstract Doc Link 630888 Disease Relevance 0.85 Pain Relevance 0.06
There was no difference in efficacy or incidence of slow HCG decline between the PG dose of 1 mg and 1.5 mg, but side effects of uterine pain, vomiting, and diarrhea (50% overall, in no case severe) were more marked with the 1.5-mg dose.
Negative_regulation (decline) of HCG in uterine associated with pain, diarrhoea, vomiting and reprotox - general 1
14) Confidence 0.38 Published 1978 Journal Contraception Section Abstract Doc Link 630888 Disease Relevance 1.07 Pain Relevance 0.10
Heavy blood loss after abortion was significantly related to slow decline in serum HCG.
Negative_regulation (decline) of HCG in blood associated with pressure volume 2 under development and reprotox - general 1
15) Confidence 0.38 Published 1978 Journal Contraception Section Abstract Doc Link 630888 Disease Relevance 0.83 Pain Relevance 0.08
FSH did not respond to NAL either before or after TP administration, though FSH levels were significantly reduced by TP.
Negative_regulation (reduced) of FSH associated with narcan
16) Confidence 0.38 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.15 Pain Relevance 0.52
The median slope for a rise of hCG after 1 day was 1.50, (or a 50% increase); 2.24 after 2 days (or a 124% rise), and 5.00 after 4 days.
Negative_regulation (rise) of hCG
17) Confidence 0.37 Published 2004 Journal Obstet Gynecol Section Body Doc Link 15229000 Disease Relevance 0 Pain Relevance 0
After the surgical procedure, the levels of hCG and estradiol rapidly decreased, and the gynecomastia resolved completely within 3 months.
Negative_regulation (decreased) of hCG
18) Confidence 0.36 Published 2003 Journal Endocr Pract Section Body Doc Link 12917067 Disease Relevance 0.15 Pain Relevance 0
Hormonal evaluation revealed high levels of hCG beta subunit, estradiol, and total and free testosterone and suppressed levels of luteinizing hormone and follicle-stimulating hormone.
Negative_regulation (suppressed) of luteinizing hormone in follicle
19) Confidence 0.36 Published 2003 Journal Endocr Pract Section Body Doc Link 12917067 Disease Relevance 0.17 Pain Relevance 0
A live fetus was demonstrated in 259 women of whom six subsequently miscarried; one of these had markedly depressed serum hCG and PAPP-A, but normal SP1 levels, and two had oligohydramnios.
Negative_regulation (depressed) of hCG associated with oligohydramnios
20) Confidence 0.34 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.56 Pain Relevance 0.09

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