INT310419

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 8 23.52 Low Low
ischemia 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
colic 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 77 97.84 Very High Very High Very High
Death 32 87.08 High High
Cancer 45 84.92 Quite High
Stomach Cancer 1 71.80 Quite High
Stress 18 71.76 Quite High
Breast Cancer 1 62.24 Quite High
Lung Cancer 27 50.00 Quite Low
Aging 2 49.16 Quite Low
Necrosis 3 46.12 Quite Low
Colon Cancer 2 43.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Negative_regulation (prevent) of Localization (release) of Bcl-2
1) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.19 Pain Relevance 0
This is not undisputed, because it has also been shown in another study that zinc can increase the expression of Bax, leading to an decreased Bcl-2/Bax ratio and the release of cytochrome-c from mitochondria [101].
Negative_regulation (decreased) of Localization (release) of Bcl-2
2) Confidence 0.14 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.85 Pain Relevance 0
Our findings reveal that OGE pretreatment increased the level of Bcl-2, suggesting that OGE's protective effects consists of the inhibition of the CytC release and apoptosome formation, resulting in the inhibition of mitochondrial pathway activation.
Negative_regulation (inhibition) of Localization (release) of Bcl-2
3) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.47 Pain Relevance 0

General Comments

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