INT310419

Context Info Confidence 0.41 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.51 Pain Relevance 0

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2) intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)

BCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 8 23.52 ischemia 6 5.00 Inflammation 4 5.00 alcohol 3 5.00 abdominal pain 3 5.00 colic 2 5.00 cytokine 2 5.00 Angina 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 77 97.84 Death 32 87.08 Cancer 45 84.92 Stomach Cancer 1 71.80 Stress 18 71.76 Breast Cancer 1 62.24 Lung Cancer 27 50.00 Aging 2 49.16 Necrosis 3 46.12 Colon Cancer 2 43.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].

Negative_regulation (prevent) of Localization (release) of Bcl-2

1) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.19 Pain Relevance 0

This is not undisputed, because it has also been shown in another study that zinc can increase the expression of Bax, leading to an decreased Bcl-2/Bax ratio and the release of cytochrome-c from mitochondria [101].

Negative_regulation (decreased) of Localization (release) of Bcl-2

2) Confidence 0.14 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.85 Pain Relevance 0

Our findings reveal that OGE pretreatment increased the level of Bcl-2, suggesting that OGE's protective effects consists of the inhibition of the CytC release and apoptosome formation, resulting in the inhibition of mitochondrial pathway activation.

Negative_regulation (inhibition) of Localization (release) of Bcl-2

3) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.47 Pain Relevance 0

General Comments

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