INT310439

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (POLA1) nuclear envelope (POLA1) DNA binding (POLA1)
cytoplasm (POLA1) cell proliferation (POLA1) nucleolus (POLA1)
Anatomy Link Frequency
blood 2
POLA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 25.72 Quite Low
headache 5 15.28 Low Low
Central nervous system 5 5.28 Low Low
psoriasis 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Versed 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Trepenoma Infection 555 98.62 Very High Very High Very High
Sexually Transmitted Diseases 35 95.44 Very High Very High Very High
Alopecia 10 94.36 High High
Exanthema 25 86.68 High High
Infection 55 77.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 65 77.16 Quite High
Disease 105 75.00 Quite High
Sprains And Strains 70 72.56 Quite High
Congenital Anomalies 5 69.48 Quite High
Acanthosis 5 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 10┬Ál sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Regulation (targets) of polA
1) Confidence 0.24 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
Using a real-time qPCR assay targeting the polA gene, we first established the sensitivity of the assay to be between 15 and 150 spirochetes/ml, irrespective of whether freshly extracted Tp DNA or live whole spirochetes were used to spike the blood sample (Table S1).
Regulation (targeting) of polA in blood
2) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.56 Pain Relevance 0
Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods.
Regulation (target) of polA in blood associated with trepenoma infection
3) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2872645 Disease Relevance 1.04 Pain Relevance 0
PCR inhibition was not observed in any of the DNA samples that tested negative for the Tp polA target.
Regulation (target) of polA
4) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.30 Pain Relevance 0
Samples were tested using a real-time PCR targeting the Tp polA gene (Gene Bank Accession No.
Regulation (targeting) of polA
5) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.22 Pain Relevance 0

General Comments

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